49592-61-2

Basic information

• Product Name: 3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE
• Synonyms: thiophene-3-ol,tetrahydro-4-chloro-,1,1-dioxide;IFLAB-BB F0880-0026;4-CHLOROTETRAHYDROTHIOPHENE-3-OL 1,1-DIOXIDE;3-CHLORO-4-HYDROXYTETRAHYDRO-1H-1LAMBDA6-THIOPHENE-1,1-DIONE;3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE;4-chlorotetrahydrothiophen-3-ol 1,1-dioxide;4-Chloro-2,3,4,5-tetrahydro-3-hydroxythiophene 1,1-dioxide;3-Chloro-4-hydroxytetrahydrothiophene 1,1-dioxide 95%
• CAS NO: 49592-61-2
• Molecular Formula: C₄H₇ClO₃S
• Molecular Weight: 170.61
• EINECS: 256-392-0
• Mol File: 49592-61-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 163 °C
• Boiling Point: 444.7°C at 760 mmHg
• Flash Point: 222.7°C
• Appearance: /
• Density: 1.6g/cm³
• Vapor Pressure: 8.94E-10mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: 3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE(49592-61-2)
• EPA Substance Registry System: 3-CHLORO-4-HYDROXYTETRAHYDROTHIOPHENE-1,1-DIOXIDE(49592-61-2)

Safety Data

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 49592-61-2(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-hydroxytetrahydrothiophene-1,1-dioxide is a chemical compound with the molecular formula C4H7ClO3S. It is a heterocyclic organic compound that contains a chlorine atom and a hydroxyl group attached to a tetrahydrothiophene ring with a 1,1-dioxide substituent. This chemical is used in various industries, including pharmaceuticals, agrochemicals, and materials science. It has been studied for its potential biological activities and has shown promise as an antibacterial and antifungal agent. Its unique structure and properties make it a valuable component in the development of new and innovative products.

InChI:InChI=1/C4H7ClO3S/c5-3-1-9(7,8)2-4(3)6/h3-4,6H,1-2H2

Upstream product

• 77-79-2 3-Sulfolene 
• 4509-11-9 3,4-epoxy-tetrahydro-thiophene-1,1-dioxide 
• 107-30-2 chloromethyl methyl ether 
• 13031-76-0 3-hydroxytetrahydrothiophene-1,1-dioxide 

Downstream Products

• 86597-94-6 4-acetoxy-2-thiolene 1,1-dioxide 
• 52200-82-5 trans-3-acetoxy-4-chlorosulfolane 
• 42925-42-8 4-chloro-2-thiolene-1,1-dioxide 
• 4509-11-9 3,4-epoxy-tetrahydro-thiophene-1,1-dioxide 
• 35895-27-3 trans-4-p-Toluidinothiolan-3-ol 1,1-dioxide 
• 35895-27-3 cis-4-p-Toluidinothiolan-3-ol 1,1-dioxide 
• 75135-14-7 (3R,4R)-4-(4-Methoxy-phenylamino)-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-ol 
• 75135-14-7 (3S,4R)-4-(4-Methoxy-phenylamino)-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-ol 
• 20688-37-3 trans-4-amino-tetrahydrothiophen-3-ol 1,1-dioxide 
• 863667-48-5 (αR,3S,4R)-3-(α-methoxyphenylacetoxy)-4-chlorotetrahydrothiophene-1,1-dioxide 

Relevant articles and documents

Oxygen-17 Nuclear Magnetic Resonance Spectral Investigation of 3-Alkoxy-trans-3,4-Disubstituted-Thiolane 1,1-Dioxides and Related Compounds

The (17)O NMR spectra of 3-alkoxythiolane 1,1-dioxides indicate that the sulfonyl oxygens are diastereotopic but their chemical shift differences are essentially independent of the structure of the alkyl group in the alkoxy moiety.Eu(fod)3 enhances the (17)O chemical shift difference between the diastereotopic sulfonyl oxygens in 3-isopropoxythiolane 1,1-dioxide and shifts both oxygens upfield. α,β-Unsaturation deshields the sulfonyl oxygens in both five- and six-membered rings.

REACTION OF SOLFOLENE OXIDES WITH ACYL CHLORIDES AND CHLORO ETHERS

The reaction of sulfolene and 3-methylsulfolene oxides with acetyl chloride, benzoyl chloride, and chlorodimethyl and chloromethyl ethyl ethers was studied.It is shown that sulfolene oxides are rather stable in acidic media and undergo ring opening only w