49674-28-4

Basic information

• Product Name: 3-amino-5-(trifluoromethyl)benzonitrile
• Synonyms: Benzonitrile, 3-aMino-5-(trifluoroMethyl)-;3-Amino-5-cyanobenzotrifluoride, 5-Cyano-alpha,alpha,alpha-trifluoro-m-toluidine;3-Amino-5-(trifluoromethyl)benzonitrile98%;3-Amino-5-(trifluoromethyl)
• CAS NO: 49674-28-4
• Molecular Formula: C₈H₅F₃N₂
• Molecular Weight: 186.1339096
• Mol File: 49674-28-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-amino-5-(trifluoromethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-5-(trifluoromethyl)benzonitrile(49674-28-4)
• EPA Substance Registry System: 3-amino-5-(trifluoromethyl)benzonitrile(49674-28-4)

Safety Data

• Hazardous Substances Data: 49674-28-4(Hazardous Substances Data)

Usage

General Description

3-amino-5-(trifluoromethyl)benzonitrile is a chemical compound with the molecular formula C8H5F3N2. It is a member of the benzonitrile family and contains a trifluoromethyl group, making it useful for certain synthetic and pharmaceutical applications. 3-amino-5-(trifluoromethyl)benzonitrile is a white to light yellow solid at room temperature and is insoluble in water but soluble in organic solvents. It is known to be a versatile building block for the synthesis of various pharmaceutical and agrochemical compounds. Additionally, 3-amino-5-(trifluoromethyl)benzonitrile is used as a reagent in organic synthesis, specifically in nucleophilic aromatic substitution reactions. It is important to handle this compound with caution as it can be harmful if ingested, inhaled, or comes into contact with the skin.

Upstream product

• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 20566-89-6 3-nitro-5-(trifluoromethyl)benzamide 
• 7440-44-0 pyrographite 
• 20566-80-7 3-nitro-5-(trifluoromethyl)benzonitrile 
• 57-14-7 N,N-Dimethylhydrazine 
• 73963-98-1 zinc cyanide 
• 54962-75-3 [3-bromo-5-(trifluoromethyl)phenyl]amine 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 691877-03-9 3-bromo-5-(trifluoromethyl)benzonitrile 
• 691877-05-1 C₈H₃F₃IN 
• 880882-04-2 1-[3-amino-5-(trifluoromethyl)phenyl]ethanone 
• 1220628-04-5 6-(3-cyano-5-(trifluoromethyl)phenylamino)-8-(isopropylamino)imidazo[1,2-b]pyridazine-3-carbonitrile 
• 1220628-13-6 6-((3-cyano-5-(trifluoromethyl)phenyl)amino)-8-((2-methoxyethyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile 
• 1220628-15-8 6-((3-cyano-5-(trifluoromethyl)phenyl)amino)-8-(methylamino)imidazo[1,2-b]pyridazine-3-carbonitrile 
• 1280200-57-8 (R)-N-(3-cyano-5-(trifluoromethyl)phenyl)-1-(2,6-dimethylphenyl)-3-isopropyl-5-oxopyrrolidine-3-carboxamide 
• 1233324-80-5 5-(aminomethyl)-3-(trifluoromethyl)aniline 
• 693249-72-8 tert-butyl [4-amino-2-(trifluoromethyl)benzyl]carbamate 
• 942072-08-4 ((R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 
• 942073-62-3 ((S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 
• 1354947-79-7 2-{[3-cyano-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate 
• 1354946-95-4 3-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-5-(trifluoromethyl)benzonitrile 
• 1354947-80-0 {1-[3-cyano-5-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl acetate 

Relevant articles and documents

INHIBITORS OF NECROPTOSIS

The invention relates to novel heterocyclic compounds of Formula (I) which inhibit necroptosis and methods for their use. The compounds may be useful in the treatment of conditions associated with deregulated necroptosis.

Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

Glucagon antagonists/inverse agonists

Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.