49758-35-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-;L-7-Azatryptophan;1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-aMino-, (S)-;(S)-2-aMino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;3-(1H-Pyrrolo[2,3-b]Pyridin-3-Yl)Alanine;(S)-2-ammonio-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoate;(2S)-2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;(aS)-a-amino-1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid
• CAS NO: 49758-35-2
• Molecular Formula: C₁₀H₁₁N₃O₂
• Molecular Weight: 205.216
• Mol File: 49758-35-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-(49758-35-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-(49758-35-2)

Safety Data

• Hazardous Substances Data: 49758-35-2(Hazardous Substances Data)

Usage

General Description

The chemical "1H-Pyrrolo[2,3-b]pyridine-3-propanoic acid, a-amino-, (aS)-" is a compound that consists of a pyrrolopyridine core with a propanoic acid side chain and an amino group. It is a chiral compound with the S configuration. This chemical may have potential applications in pharmaceuticals or biochemistry due to its unique structure and functional groups. Further research and testing would be needed to determine its exact properties and potential uses.

Upstream product

• 63024-18-0 N^α-Acetyl-DL-7-azatryptophan 
• 211179-97-4 diethyl 2-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-2-acetamidomalonate 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 271-63-6 7-Azaindole 
• 56-45-1 L-serin 
• 7303-50-6 7-azatryptophan 

Downstream Products

• 1200129-86-7 C₂₂H₂₁N₅O₂ 
• 1200129-93-6 C₂₂H₂₂N₆O 
• 1200127-66-7 3-(4-(4-methylpiperazin-1-yl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine-6-carbonitrile 
• 4649-12-1 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-ethylamine 

Relevant articles and documents

Deracemization and stereoinversion to aromatic d-amino acid derivatives with ancestral l-amino acid oxidase

Enantiomerically pure amino acid derivatives could be foundational compounds for peptide drugs. Deracemization of racemates to l-amino acid derivatives can be achieved through the reaction of evolved d-amino acid oxidase and chemical reductants, whereas deracemization to d-amino acid derivatives has not progressed due to the difficulty associated with the heterologous expression of l-amino acid oxidase (LAAO). In this study, we succeeded in developing an ancestral LAAO (AncLAAO) bearing broad substrate selectivity (13 l-amino acids) and high productivity through an Escherichia coli expression system (50.7 mg/L). AncLAAO can be applied to perform deracemization to d-amino acids in a similar way to deracemization to l-amino acids. In fact, full conversion (>99% ee, d-form) could be achieved for 16 racemates, including nine d,l-Phe derivatives, six d,l-Trp derivatives, and a d,l-phenylglycine. Taken together, we believe that AncLAAO could be a key enzyme to obtain optically pure d-amino acid derivatives in the future.

Palladium-catalyzed heteroannulation approach to 7-azatryptophan with a Sch?llkopf chiral auxiliary

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