49802-15-5

Basic information

• Product Name: diethyl (4-chlorophenyl)phosphoramidate
• Synonyms: diethyl (4-chlorophenyl)phosphoramidate
• CAS NO: 49802-15-5
• Molecular Weight: 263.661
• Mol File: 49802-15-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: diethyl (4-chlorophenyl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-chlorophenyl)phosphoramidate(49802-15-5)
• EPA Substance Registry System: diethyl (4-chlorophenyl)phosphoramidate(49802-15-5)

Safety Data

• Hazardous Substances Data: 49802-15-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 6971-73-9 N-p-chlorophenylphosphoramidic dichloride 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 762-04-9 phosphonic acid diethyl ester 
• 762-04-9 Diethyl phosphonate 
• 106-47-8 4-chloro-aniline 
• 3296-05-7 1-azido-4-chlorobenzene 
• 6374-26-1 diethyl phosphorisothiocyanatidate 
• 100-00-5 4-chlorobenzonitrile 
• 122-52-1 triethyl phosphite 
• 3289-75-6 2-chloro-N-(4-chlorophenyl)acetamide 
• 814-49-3 diethyl chlorophosphate 

Downstream Products

• 55560-25-3 C₁₈H₂₇ClNO₆P 
• 90945-41-8 Diaethyl-N-chlor-N-p-chlorphenylphosphoramidat 
• 2400-95-5 3-(4-chlorophenyl)-1H,3H-quinazolin-2,4-dione 
• 90945-42-9 (2,4-dichloro-phenyl)-amidophosphoric acid diethyl ester 
• 1266570-23-3 diethyl 4-chlorophenyl(1,3,3-triphenylpropa-1,2-dienyl)phosphoramidate 
• 1266570-42-6 2-(4-chlorophenyl)-1,3,4,9,9-pentaphenyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 

Relevant articles and documents

Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates

A practical phosphorylation for generating organophosphates and phosphoramidatesviaelectrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.

Organophotocatalytic Synthesis of Phosphoramidates

We describe the use of visible light in conjunction with an organic dye for the synthesis of phosphoramidates. Cross dehydrogenative coupling reactions between phosphites and amines are reported using organic dyes and light as catalysts for the first time. It is not only a novel application of organic dyes but also fulfils the requirement of sustainability and green chemistry avoiding the use of chromatographic purification techniques. The product was simply isolated from the reaction mixture via an acid-base work-up procedure, rendering the pure product in good yields.

An efficient and convenient procedure for the one-pot synthesis of α-aminophosphonates from aryl azides under solvent-free conditions

A novel and simple approach to the multicomponent one-pot reaction of aldehydes, diethyl phosphite, and azides to form α-aminophosphonates under solvent-free conditions at room temperature has been developed. In the presence of iodine and iron, aryl azides were, for the first time, used as substrates for the synthesis of α-aminophosphonates. The reactions were completed within 5 minutes to 12 hours and afforded the corresponding products in good yields.