498548-17-7

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-
• CAS NO: 498548-17-7
• Molecular Formula: C35H24O7
• Molecular Weight: 556.571
• Mol File: 498548-17-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-(498548-17-7)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-(498548-17-7)

Safety Data

• Hazardous Substances Data: 498548-17-7(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 357194-03-7 2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one 
• 1258551-29-9 acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester 
• 1258551-28-8 acetic acid 3,5-diacetoxy-2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-4-oxo-4H-chromen-7-yl ester 
• 117-39-5 quercetol 
• 2051-90-3 Dichlorodiphenylmethane 
• 100-39-0 benzyl bromide 

Downstream Products

• 1144104-70-0 C₃₈H₂₈O₉ 
• 1192218-30-6 C₆₈H₇₆O₁₀ 
• 1313191-78-4 2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-3,5-bisbenzyloxy-7-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranosyloxy-4H-chromen-4-one 
• 1313191-79-5 2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-3,5-bisbenzyloxy-7-β-D-glucopyranosyloxy-4H-chromen-4-one 
• 491-50-9 quercetin 7-O-β-D-glucopyranoside 
• 38934-20-2 Quercetin 7-glucuronide 
• 1313191-77-3 2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-3-benzyloxy-5-hydroxyl-7-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranosyloxy-4H-chromen-4-one 
• 1393953-78-0 3-(benzyloxy)-2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dimethoxy-4H-chromen-4-one 
• 498548-19-9 3-(benzyloxy)-2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5-hydroxy-7-methoxy-4H-chromen-4-one 
• 552-54-5 rhamnazin 

Relevant articles and documents

Synthesis of Rhamnazin and Ombuin as methylated metabolites of quercetin

The methylated metabolites of quercetin, rhamnazin and ombuin are highly likely to develop as anticancer and anti-inflammatory agents. In this study, we synthesized rhamnazin through selective methylation of quercetin hydroxyl group, which has not been reported so far. In addition, a new synthetic method was developed to correct the problems of previous synthetic method of ombuin, one of the methylated metabolites of quercetin.

Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance

Quercetin-amino acid conjugates with alanine or glutamic acid moiety attached at 7-O and/or 3-O position of quercetin were prepared, and their multidrug resistance (MDR)-modulatory effects were evaluated. A quercetin-glutamic acid conjugate, 7-O-Glu-Q (3a

Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors

In blood, quercetin is mainly found in metabolized forms. In order to study the activities of these quercetin metabolites in cardiovascular disease, 17 methylquercetin derivatives were synthesized based on metabolism in vivo, their thrombin inhibition activity were evaluated through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). The results showed that 6 methylquercetin derivatives had stronger inhibitory activities than that of quercetin. Preliminary SARs analysis showed that hydroxyl groups at C-3′ and C-4′ position in the B-ring and hydroxyl group at C-3 position in the C-ring played key roles in the thrombin inhibitory activity. The findings of this study would provide information for the exploitation and utilization of quercetin as thrombin inhibitor for thrombotic disease treatment.