5002-98-2 Usage
Description
(R)-2-((3-bromophenoxy)methyl)oxirane is a stereoisomer of a chemical compound that features an oxirane ring, which is a three-membered cyclic ether with a strained ring structure. (R)-2-((3-bromophenoxy)methyl)oxirane also includes a 3-bromophenoxy group, where a bromine atom is attached to the third carbon atom of a phenyl group, and a methyl group. Due to its structural characteristics, it may find applications in various fields such as organic synthesis, pharmaceuticals, and as a starting material for the production of other chemicals. However, it is crucial to handle and store this compound with care, considering its potential reactivity and toxicity.
Uses
Used in Organic Synthesis:
(R)-2-((3-bromophenoxy)methyl)oxirane is used as an intermediate in the synthesis of various organic compounds due to its unique structural features, including the strained oxirane ring and the 3-bromophenoxy group. Its reactivity can be exploited to form a range of derivative molecules for different applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-2-((3-bromophenoxy)methyl)oxirane is used as a building block for the development of new drugs. Its specific stereochemistry and functional groups can be utilized to create molecules with potential therapeutic properties, targeting various medical conditions.
Used as a Starting Material for Chemical Production:
(R)-2-((3-bromophenoxy)methyl)oxirane serves as a starting material for the production of other chemicals, leveraging its structural attributes to synthesize a variety of compounds for different industrial applications. Its versatility in chemical reactions makes it a valuable precursor in the chemical manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 5002-98-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,0 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5002-98:
(6*5)+(5*0)+(4*0)+(3*2)+(2*9)+(1*8)=62
62 % 10 = 2
So 5002-98-2 is a valid CAS Registry Number.
5002-98-2Relevant articles and documents
Substituted diaryl compound and preparation method and application thereof
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Paragraph 0073-0075; 0076, (2021/09/15)
The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666
Duncan, Kenneth W.,Rioux, Nathalie,Boriack-Sjodin, P. Ann,Munchhof, Michael J.,Reiter, Lawrence A.,Majer, Christina R.,Jin, Lei,Johnston, L. Danielle,Chan-Penebre, Elayne,Kuplast, Kristy G.,Porter Scott, Margaret,Pollock, Roy M.,Waters, Nigel J.,Smith, Jesse J.,Moyer, Mikel P.,Copeland, Robert A.,Chesworth, Richard
supporting information, p. 162 - 166 (2016/03/01)
The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool compound EPZ015666 (GSK3235025) to probe the underlying pharmacology of this key enzyme. Herein, we report the design and optimization strategies employed on an initial hit compound with poor in vitro clearance to yield in vivo tool compound EPZ015666 and an additional potent in vitro tool molecule EPZ015866 (GSK3203591).
PRMT5 INHIBITORS AND USES THEREOF
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Paragraph 00319, (2014/07/08)
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described
