502842-12-8

Basic information

• Product Name: Ethyl 3-amino-3-(p-tolyl)propanoate HCl
• Synonyms: Ethyl 3-amino-3-(p-tolyl)propanoate HCl
• CAS NO: 502842-12-8
• Molecular Weight: 243.733
• Mol File: 502842-12-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethyl 3-amino-3-(p-tolyl)propanoate HCl(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-amino-3-(p-tolyl)propanoate HCl(502842-12-8)
• EPA Substance Registry System: Ethyl 3-amino-3-(p-tolyl)propanoate HCl(502842-12-8)

Safety Data

• Hazardous Substances Data: 502842-12-8(Hazardous Substances Data)

Usage

General Description

Ethyl 3-amino-3-(p-tolyl)propanoate HCl is a chemical compound that consists of an ethyl group, an amino group, and a p-tolyl group attached to a propanoate molecule, along with a hydrochloride (HCl) salt. Ethyl 3-amino-3-(p-tolyl)propanoate HCl is commonly used in the synthesis of pharmaceuticals and other organic compounds. It may also be used as a reagent or intermediate in chemical reactions. The presence of the HCl salt indicates that it is a hydrochloride salt of the compound, which can affect its solubility and other chemical properties. Ethyl 3-amino-3-(p-tolyl)propanoate HCl has potential applications in the pharmaceutical industry and in organic chemistry research.

Upstream product

• 402828-06-2 (R)-1-butyryloxymethyl-4-(p-tolyl)-2-azetidinone 
• 402827-98-9 1-butyryloxymethyl-4-(p-tolyl)-2-azetidinone 
• 64-17-5 ethanol 
• 402828-09-5 (R)-1-hydroxymethyl-4-(p-tolyl)-2-azetidinone 
• 104-87-0 4-methyl-benzaldehyde 
• 68208-18-4 3-amino-3-(p-tolyl)propionic acid 
• 402827-97-8 1-hydroxymethyl-4-(p-tolyl)-2-azetidinone 
• 21161-19-3 (+/-)-4-(p-tolyl)-2-azetidinone 
• 622-97-9 1-ethenyl-4-methylbenzene 

Relevant articles and documents

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents

Antagonism of αvβ6 is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an αvβ3 antagonist lead and through simple variation in the nature and position of the aryl substituent, the discovery of compounds with improved αvβ6 activity is described. The compounds also have physicochemical properties commensurate with oral bioavailability and are high quality starting points for a drug discovery program. Compounds 33S and 43E1 are pan αv antagonists having ca. 100 nM potency against αvβ3, αvβ5, αvβ6, and αvβ8 in cell adhesion assays. Detailed structure activity relationships with these integrins are described which also reveal substituents providing partial selectivity (defined as at least a 0.7 log difference in pIC50 values between the integrins in question) for αvβ3 and αvβ5.

Synthesis of 4-aryl-substituted β-lactam enantiomers by enzyme-catalyzed kinetic resolution

Enantiopure 4-phenyl- and 4-(p-tolyl)-2-azetidinones 3a, 3b, 4a and 4b (with e.e.s of ≥96%) were prepared through lipase-catalyzed asymmetric butyrylation of the primary OH group of N-hydroxymethylated β-lactams (±)-5 and (±)-6 at the (R)-stereogenic centre or by lipase-catalyzed asymmetric debutyrylation of O-butyryloxymethyl-2-azetidinones (±)-7 and (±)-8 at the (R)-stereogenic centre. The ring-opening of lactams 5a, 5b, 6b and 8a with HCl/EtOH afforded the corresponding β-amino ester enantiomers 9a, 9b, 10a and 10b with e.e.s of ≥92%.