50423-49-9

Basic information

• Product Name: 1,2-bis(iodomethyl)benzene
• Synonyms: 1,2-bis(iodomethyl)benzene
• CAS NO: 50423-49-9
• Molecular Weight: 357.961
• Mol File: 50423-49-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,2-bis(iodomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(iodomethyl)benzene(50423-49-9)
• EPA Substance Registry System: 1,2-bis(iodomethyl)benzene(50423-49-9)

Safety Data

• Hazardous Substances Data: 50423-49-9(Hazardous Substances Data)

Usage

Appearance

White to light yellow crystalline solid

Usage

a. Synthesis of other organic compounds
b. Building block in the production of specialty chemicals
c. Building block in the production of pharmaceuticals
d. Building block in the production of agricultural products

Role in organic chemistry

a. Ability to form carbon-carbon bonds
b. Undergoes various functional group transformations

Additional uses

a. Precursor for the synthesis of polymers
b. Precursor for the synthesis of materials with specific properties

Safety precautions

Handle with care due to toxic and potentially harmful effects

Upstream product

• 4254-29-9 indan-2-ol 
• 612-14-6 phthalyl alcohol 
• 7553-56-2 iodine 
• 91-13-4 α,α'-dibromo-o-xylene 
• 85-44-9 phthalic anhydride 
• 75504-47-1 ((C₂H₅)3P)2Pt(CH₂)2C₆H₄ 
• 89-92-9 2-methylbenzyl bromide 

Downstream Products

• 69403-16-3 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester 
• 68376-10-3 3-phenylnaphthalene-2-carbonitrile 
• 32796-95-5 1,2-dimethylenebenzene 
• 1415334-90-5 ethyl 3-(4-nitrophenyl)-2-naphthoate 
• 886050-81-3 1,2-bis(3-(trimethylsilyl)prop-2-yn-1-yl)benzene 
• 1196989-82-8 1,2-bis((1H-1,2,4-triazol-1-yl)methyl)benzene 
• 78239-34-6 1,1-difluoro-1H-cyclopropanthracene 
• 287-03-6 1H-cyclopropaanthracene 
• 50423-48-8 1,2-di(prop-2-yn-1-yl)benzene 

Relevant articles and documents

Reaction of the C60 radical anion with alkyl halides

The reaction of the C60 radical anion (C60-) with α-bromo-1,3-dicarbonyl compounds selectively afforded the methanofullerene derivatives. The reaction with benzyl halide and 1,2-bis(dihalomethyl)benzene afforded the corresponding 1,4-dibenzylated C60 derivative and cycloaddition product, respectively. The possible mechanisms for the formation of the fullerene adducts are proposed.

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

2,6-Diazasemibullvalenes: Synthesis, structural characterization, reaction chemistry, and theoretical analysis

A series of 2,6-diazasemibullvalenes (NSBVs) were synthesized and isolated from the reaction of 1,4-dilithio-1,3-dienes with nitriles via oxidant-induced C-N bond formation. For the first time, the activation barrier and an X-ray crystal structure of a su