5048-50-0

Basic information

• Product Name: DIETHYL TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLATE
• Synonyms: TRANS-1,2,3,6-TETRAHYDROPHTHALIC ACID DIETHYL ESTER;TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ACID DIETHYL ESTER;DIETHYL TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLATE;DIETHYL TRANS-1,2,3,6-TETRAHYDROPHTHALATE;trans-4-Cyclohexene-1,2-dicarboxylic Acid Diethyl Ester Diethyl trans-1,2,3,6-Tetrahydrophthalate trans-1,2,3,6-Tetrahydrophthalic Acid Diethyl Ester;Diethyl trans-4-Cyclohexene-1,2-dicarboxylate;trans-Diethyl cyclohex-4-ene-1,2-dicarboxylate
• CAS NO: 5048-50-0
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.27
• Mol File: 5048-50-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 293.501 °C at 760 mmHg
• Flash Point: 138.147 °C
• Appearance: /
• Density: 1.064
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.4560-1.4600
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DIETHYL TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLATE(5048-50-0)
• EPA Substance Registry System: DIETHYL TRANS-4-CYCLOHEXENE-1,2-DICARBOXYLATE(5048-50-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 5048-50-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C12H18O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-6,9-10H,3-4,7-8H2,1-2H3/t9-,10-/m0/s1

Upstream product

• 106-99-0 buta-1,3-diene 
• 623-91-6 diethyl Fumarate 
• 77-79-2 3-Sulfolene 
• 64-17-5 ethanol 

Downstream Products

• 13149-04-7 (rac)-trans-4,5-bis(hydroxymethyl)cyclohex-1-ene 
• 96836-97-4 diethyl cyclohexane-trans-1,2-dicarboxylate 
• 118374-48-4 (1S,2S,4S,5S)-4-Acetoxy-5-phenylselanyl-cyclohexane-1,2-dicarboxylic acid diethyl ester 
• 14246-80-1 (1S*,2S*)-cyclohex-4-ene-1,2-dicarbohydrazide 
• 76155-27-6 (+/-)-trans-2-(hydroxymethyl)cyclohexylmethanol 

Relevant articles and documents

Synthesis of 1,4-Cyclohexanedimethanol, 1,4-Cyclohexanedicarboxylic Acid and 1,2-Cyclohexanedicarboxylates from Formaldehyde, Crotonaldehyde and Acrylate/Fumarate

Valuable polyester monomers and plasticizers—1,4-cyclohexanedimethanol (CHDM), 1,4-cyclohexanedicarboxylic acid (CHDA), and 1,2-cyclohexanedicarboxylates—have been prepared by a new strategy. The synthetic processes involve a proline-catalyzed formal [3+1+2] cycloaddition of formaldehyde, crotonaldehyde, and acrylate (or fumarate). CHDM is produced after a subsequent hydrogenation step over a commercially available Cu/Zn/Al catalyst and a one-pot hydrogenation/oxidation/hydrolysis process yields CHDA, whereas 1,2-cyclohexanedicarboxylate is obtained by a Pd/C-catalyzed tandem decarbonylation/hydrogenation step.

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition

The strong acid triflimide ((CF3SO2)2NH) protonates chiral oxazaborolidines to form superactive, stable, chiral Lewis acids which are highly effective catalysts for a wide variety of enantioselective Diels-Alder reactions, documented herein by more than 20 examples. Copyright