50627-31-1

Basic information

• Product Name: 2-Iodo-3-Methoxybenzoic acid
• Synonyms: 2-Iodo-3-Methoxybenzoic acid;Benzoic acid, 2-iodo-3-Methoxy-
• CAS NO: 50627-31-1
• Molecular Formula: C₈H₇IO₃
• Molecular Weight: 278.04385
• Mol File: 50627-31-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Iodo-3-Methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-3-Methoxybenzoic acid(50627-31-1)
• EPA Substance Registry System: 2-Iodo-3-Methoxybenzoic acid(50627-31-1)

Safety Data

• Hazardous Substances Data: 50627-31-1(Hazardous Substances Data)

Usage

Description

2-Iodo-3-Methoxybenzoic acid is a chemical compound with the molecular formula C8H7IO4. It is a derivative of benzoic acid with a 2-iodo-3-methoxy substituent, known for its potential applications in various fields.
Used in Pharmaceutical Industry:
2-Iodo-3-Methoxybenzoic acid is used as a building block for the preparation of various pharmaceuticals. It plays a crucial role in the synthesis of new molecules with potential therapeutic properties, making it a valuable resource for drug discovery and development.
Used in Agrochemical Industry:
2-Iodo-3-Methoxybenzoic acid is used as a building block for the preparation of various agrochemicals. Its unique structure and properties make it a useful component in the development of new agrochemicals with improved efficacy and safety.
Used in Medicinal Chemistry:
2-Iodo-3-Methoxybenzoic acid is used as a reagent in the preparation of biologically active compounds. Its presence in the synthesis process contributes to the creation of molecules with potential applications in treating various diseases and conditions.
Used in Material Science:
2-Iodo-3-Methoxybenzoic acid is used in the development of new materials. Its unique chemical properties make it a promising candidate for the creation of innovative materials with a wide range of applications.
Overall, 2-Iodo-3-Methoxybenzoic acid is a versatile chemical compound with significant applications across multiple industries, making it an important resource for researchers and chemists working on the design and synthesis of new molecules with potential therapeutic properties.

Upstream product

• 586-38-9 3-Methoxybenzoic acid 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 4920-77-8 3-methyl-2-nitrophenol 
• 5345-42-6 1-methoxy-3-methyl-2-nitro-benzene 
• 108-39-4 3-methyl-phenol 
• 3177-80-8 2-amino-3-methoxybenzoic acid 
• 115378-20-6 3-methoxy-2-pivalamidobenzoic acid 
• 35387-95-2 methyl-2-iodo-3-methoxybenzoate 
• 5121-34-6 methyl 2-amino-3-methoxybenzoate 

Downstream Products

• 35387-95-2 methyl-2-iodo-3-methoxybenzoate 
• 945858-23-1 C₈H₆IN₃O₂ 
• 1668-07-1 dl-dehydrogliotoxin 
• 79247-63-5 (1R,5R)-6-(2-Hydroxymethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 565433-79-6 2-(2,5-Bis-acetylsulfanyl-4-methyl-3,6-dioxo-piperazin-1-yl)-3-methoxy-benzoic acid methyl ester 
• 79247-64-6 C₂₁H₂₀N₂O₄S₂ 
• 50627-34-4 3-methoxy-2-[3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-benzoic acid methyl ester 
• 79247-65-7 (1S,3R,5S)-1-Benzyloxymethyl-6-(2-chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-04-6 (1R,3R,5R)-6-(2-Chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 49593-04-6 (1R,3S,5R)-6-(2-Chloromethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 79247-67-9 C₂₁H₂₀N₂O₅S₂ 
• 79247-67-9 C₂₁H₂₀N₂O₅S₂ 
• 79247-66-8 C₂₉H₂₈N₂O₅S₂ 
• 79247-66-8 C₂₉H₂₈N₂O₅S₂ 

Relevant articles and documents

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. The therapeutic potential of MAGL is linked to several diseases, including cancer. The development of MAGL inhibitors has been greatly limited by the side effects associated with the prolonged MAGL inactivation. Importantly, it could be preferable to use reversible MAGL inhibitors in vivo, but nowadays only few reversible compounds have been developed. In the present study, structural optimization of a previously developed class of MAGL inhibitors led to the identification of compound 23, which proved to be a very potent reversible MAGL inhibitor (IC50 = 80 nM), selective for MAGL over the other main components of the endocannabinoid system, endowed of a promising antiproliferative activity in a series of cancer cell lines and able to block MAGL both in cell-based as well as in vivo assays.

Design, synthesis and anticancer activity evaluation of diazepinomicin derivatives

A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.

First general, direct, and regioselective synthesis of substituted methoxybenzoic acids by ortho metalation

(Chemical Equation Presented) New general methodology of value in aromatic chemistry based on ortho-metalation sites in o-, m-, and p-anisic acids (1-3) (Scheme 1) is described. The metalation can be selectively directed to either of the ortho positions by varying the base, metalation temperature, and exposure times. Metalation of o-anisic acid (1) with s-BuLi/TMEDA in THF at -78°C occurs exclusively in the position adjacente to the carboxylate. On the other hand, a reversal of regioselectivity is observed with n-BuLi/t-BuOK. With LTMP at 0°C, the two directors of m-anisic acid (2) function in concert to direct introduction of the metal between them while n-BuLi/t-BuOK removes preferentially the proton located ortho to the methoxy and para to the carboxylate (H-4). s-BuLi/TMEDA reacts with p-anisic acid (3) exclusively in the vicinity of the carboxylate. According to these methodologies, routes to very simple methoxybenzoic acids with a variety of functionalities that are not easily accessible by other means have been developed (Table 1).