50670-74-1Relevant articles and documents
Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
Skerlj, Renato,Bridger, Gary,McEachern, Ernie,Harwig, Curtis,Smith, Chris,Wilson, Trevor,Veale, Duane,Yee, Helen,Crawford, Jason,Skupinska, Krystyna,Wauthy, Rossana,Yang, Wen,Zhu, Yongbao,Bogucki, David,Di Fluri, Maria,Langille, Jonathon,Huskens, Dana,De Clercq, Erik,Schols, Dominique
supporting information; experimental part, p. 262 - 266 (2011/02/27)
An early lead from the AMD070 program was optimized and a structure-activity relationship was developed for a novel series of heterocyclic containing compounds. Potent CXCR4 antagonists were identified based on anti-HIV-1 activity and Ca2+ flux
