50715-49-6

Basic information

• Product Name: Butanoic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, phenylmethyl ester, (R)-
• CAS NO: 50715-49-6
• Molecular Formula: C16H22N2O5
• Molecular Weight: 322.361
• Mol File: 50715-49-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, phenylmethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, phenylmethyl ester, (R)-(50715-49-6)
• EPA Substance Registry System: Butanoic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, phenylmethyl ester, (R)-(50715-49-6)

Safety Data

• Hazardous Substances Data: 50715-49-6(Hazardous Substances Data)

Upstream product

• 63228-51-3 L-aspartic acid beta-benzyl ester 
• 147291-69-8 4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanoic acid 
• 51186-58-4 4-benzyl Boc-D-aspartate 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 1548864-83-0 3-tert-butoxycarbonylamino-3-(1H-tetrazol-5-yl)propionic acid benzyl ester 
• 1548864-78-3 3-tert-butoxycarbonylamino-3-cyanopropionic acid benzyl ester 

Relevant articles and documents

Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis

The bacterial cell wall peptidoglycan contains unusual l- and d-amino acids assembled as branched peptides. Insight into the biosynthesis of the polymer has been hampered by limited access to substrates and to suitable polymerization assays. Here we report the full synthesis of the peptide stem of peptidoglycan precursors from two pathogenic bacteria, Enterococcus faecium and Mycobacterium tuberculosis, and the development of a sensitive post-derivatization assay for their cross-linking by l,d-transpeptidases. Access to series of stem peptides showed that amidation of free carboxyl groups is essential for optimal enzyme activity, in particular the amidation of diaminopimelate (DAP) residues for the cross-linking activity of the l,d-transpeptidase LdtMt2 from M. tuberculosis. Accordingly, construction of a conditional mutant established the essential role of AsnB indicating that this DAP amidotransferase is an attractive target for the development of anti-mycobacterial drugs.

CYSTATHIONINE-Y-GAMMA-LYASE (CSE) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ- lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treatin

Total synthesis of nosiheptide. Synthesis of thiazole fragments

The preparation of three new thiazole derivatives from natural products is described, as well as improvements in the synthesis of ethyl 2-aminomethyl-4-thiazolecarboxylate.