50731-96-9

Basic information

• Product Name: 3-O-Methyl-6-oxo 17β-Estradiol
• Synonyms: 3-O-Methyl-6-oxo 17β-Estradiol
• CAS NO: 50731-96-9
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.39206
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 50731-96-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane
• CAS DataBase Reference: 3-O-Methyl-6-oxo 17β-Estradiol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-Methyl-6-oxo 17β-Estradiol(50731-96-9)
• EPA Substance Registry System: 3-O-Methyl-6-oxo 17β-Estradiol(50731-96-9)

Safety Data

• Hazardous Substances Data: 50731-96-9(Hazardous Substances Data)

Usage

Chemical Properties

Pink Solid

Uses

Different sources of media describe the Uses of 50731-96-9 differently. You can refer to the following data:
1. Estradiol derivative. Used in the preparation of contraceptive steroids.
2. As a Estradiol derivative, 3-O-Methyl-6-oxo 17β-Estradiol can be used in the preparation of contraceptive steroids.

Upstream product

• 571-92-6 6-ketoestradiol 
• 77-78-1 dimethyl sulfate 
• 174497-42-8 (8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-17-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthren-6-one 
• 74-88-4 methyl iodide 
• 434-22-0 19-nortestosterone 
• 434-22-0 19-nortestosterone 
• 147802-61-7 6-oxoestra-1,3,5(10)-triene-3,17β-diyl dipropionate 
• 473882-84-7 3-methoxy-17β-(2-tetrahydropyranyloxy)estra-1,3,5-trien-6-ol 
• 67-56-1 methanol 
• 1020110-71-7 2-methyl-2-(2-nitroethyl)-1,3-cyclopentanedione 
• 1963-36-6 4-methoxycinnamaldehyde 

Downstream Products

• 107612-19-1 6α-(p-benzyloxyphenyl)-6β-hydroxy-estra-1,3,5(10)-triene-3,17β-diol 3-methyl ether 
• 107612-18-0 6β-(p-Benzyloxyphenyl)-6α-hydroxy-estra-1,3,5(10)-triene-3,17β-diol 3-methyl ether 
• 107612-16-8 6-Phenyl-estra-1,3,5(10),6-tetraene-3,17β-diol 3-methyl ether 
• 7291-47-6 3-Methoxy-6α,17β-dihydroxy-oestratrien-<1,3,5(10)> 
• 1035-77-4 3-O-methyl-17β-oestradiol 

Relevant articles and documents

Synthesis of (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer.

The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial((R))), (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (35), and its 7-epimer, (3alpha,7alpha,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (11), are described.

Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17- triol, a metabolite of ORG OD14, and its 7-epimer

The syntheses of the 7β-hydroxy metabolite of ORG OD14 (Livial), (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (35), and its 7-epimer, (3α,7α,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17- triol (11), are described. (C) 2000 Elsevier Science Inc.

PROCESS FOR THE PREPARATION OF STEROID DERIVATIVES

A method of producing 3-alkoxy-1,3,5(10)-triene-6-one-steroid derivatives having, in the steroid skeleton thereof, a partial structure of A- and B-rings represented by formula (2) : (wherein R represents an alkyl group, a cycloalkyl group, an alkenyl group, or an aralkyl group), including reacting a 19-norsteroid derivative having, in the steroid skeleton thereof, a partial structure of A- and B-rings represented by formula (1) : with an alcohol represented by ROH (wherein R has the same meaning as defined above) and iodine in the absence of a rare earth compound catalyst. According to the method of the present invention, 3-alkoxy-1,3,5(10)-triene-6-one-steroids can be selectively produced from 19-norsteroides through a single reaction step without employment of a special catalyst.