50786-93-1

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-phenyl-
• CAS NO: 50786-93-1
• Molecular Formula: C11H12N4O2
• Molecular Weight: 232.242
• Mol File: 50786-93-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-phenyl-(50786-93-1)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-1-phenyl-(50786-93-1)

Safety Data

• Hazardous Substances Data: 50786-93-1(Hazardous Substances Data)

Upstream product

• 42212-19-1 6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione 
• 1007-36-9 1-methyl-3-phenylurea 
• 72702-74-0 N-cyanoacetyl-N-methyl-N'-phenyl-urea 
• 72702-75-1 1-phenyl-3-methyl-5-nitroso-6-amino uracil 
• 7664-41-7 ammonia 
• 7732-18-5 water 

Downstream Products

• 301206-07-5 N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(2-oxo-2H-chromen-7-yloxy)-acetamide 
• 176379-00-3 acetic acid 2,3-diacetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester 
• 176378-82-8 N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxy-benzamide 
• 301206-05-3 acetic acid 2-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-6-methyl-phenyl ester 
• 176379-12-7 acetic acid 2-acetoxy-5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-phenyl ester 
• 301206-12-2 N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-acetamide 
• 301206-04-2 acetic acid 5-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-2-methyl-phenyl ester 
• 301206-02-0 acetic acid 4-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-2-methyl-phenyl ester 
• 204980-81-4 (S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione 
• 72702-77-3 3,7-dihydro-1-methyl-3-phenyl-8-propyl-1H-purine-2,6-dione 
• 176379-50-3 8-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-(4-methoxyphenyl)-1-methylpurine-2,6-dione 
• 176379-51-4 8-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-methyl-3-(4-methylphenyl)purine-2,6-dione 
• 176379-52-5 8-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-(4-fluorophenyl)-1-methylpurine-2,6-dione 
• 176379-57-0 1-methyl-3-phenyl-8-(3,4,5-trihydroxyphenyl)purine-2,6-dione 

Relevant articles and documents

Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.

1-arylpyrimidine derivatives and pharmaceutical use thereof

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): STR1 wherein R1 is H, alkyl or aralkyl; Ar is 1-naphthyl, or a substituted or unsubstituted phenyl group; R4 is a substituted phenyl, a substituted styryl, 1-methylcyclohexyl, 4-methylcyclohexyl, 4-oxo-4H-pyran-2-yl or 2-oxo-2H-pyran-5-yl group; R5 and R6 are each independently H or alkyl; R3 is H, and R7 and R8 are combined together to be oxo, or else R3 and R7 are combined together to be another direct bond, and R5 and R8 are combined together to be a direct bond, or pharmaceutically acceptable salts thereof; and methods for treating allergic diseases with such compounds.