72702-74-0 Usage
Description
1-(2-CYANO-ACETYL)-1-METHYL-3-PHENYL-UREA, a chemical compound with the molecular formula C11H12N4O2, is a urea derivative featuring a cyano-acetyl group attached to the nitrogen atom. It is known for its significant role in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
1-(2-CYANO-ACETYL)-1-METHYL-3-PHENYL-UREA is used as an intermediate for the preparation of pharmaceuticals. Its unique chemical properties make it a valuable compound in the development of potential drug candidates, particularly for the treatment of various diseases and disorders.
Used in Agrochemical Industry:
In addition to its pharmaceutical applications, 1-(2-CYANO-ACETYL)-1-METHYL-3-PHENYL-UREA is also utilized as an intermediate in the preparation of agrochemicals. This highlights its versatility and importance in the field of chemical compound development for different industries.
Used in Drug Discovery and Development:
1-(2-CYANO-ACETYL)-1-METHYL-3-PHENYL-UREA holds promise in the field of drug discovery and development due to its potential applications in treating a wide range of diseases and disorders. Its study aids in understanding the structure-activity relationships in pharmaceutical research, which is crucial for designing effective and safe medications.
Check Digit Verification of cas no
The CAS Registry Mumber 72702-74-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,0 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 72702-74:
(7*7)+(6*2)+(5*7)+(4*0)+(3*2)+(2*7)+(1*4)=120
120 % 10 = 0
So 72702-74-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H11N3O2/c1-14(10(15)7-8-12)11(16)13-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,13,16)
72702-74-0Relevant articles and documents
Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction
Tobe, Masanori,Isobe, Yoshiaki,Goto, Yuso,Obara, Fumihiro,Tsuchiya, Masami,Matsui, Junko,Hirota, Kosaku,Hayashi, Hideya
, p. 2037 - 2047 (2007/10/03)
In order to find novel nonsteroidal compounds possessing an inhibitory activity against delayed-type hypersensitivity (DTH) reactions, we conducted random screening using a picryl chloride (PC)-induced contact hypersensitivity reaction (CHR) in mice, and found compound 1 as a lead compound. Then we synthesized and evaluated an extensive series of 5-carboxamidouracil derivatives focused on both the uracil and the antioxidative moieties. Among them, we found that the hindered phenol moiety was necessary to exhibit the activities; especially, compounds 28a-28c having the partial structure of vitamin E were found to exert potent activities against the DTH reaction by both oral and topical administration. And compound 28c showed antioxidative activity against lipid peroxidation with an IC50 of 5.9μM. Compound 28c (CX-659S) was chosen as a candidate drug for the treatment of cutaneous disorders such as atopic dermatitis and allergic contact dermatitis. Copyright (C) 2000 Elsevier Science Ltd.