50834-78-1

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE
• Synonyms: 4-(4-Methoxyphenyl)-2-methyl-1,3-thiazole; 4-(4-Methoxy-phenyl)-2-methyl-thiazole; thiazole, 4-(4-methoxyphenyl)-2-methyl-
• CAS NO: 50834-78-1
• Molecular Formula: C₁₁H₁₁NOS
• Molecular Weight: 205.28
• Mol File: 50834-78-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 64-69℃
• Boiling Point: 334.1°Cat760mmHg
• Flash Point: 155.8°C
• Appearance: Cream/Solid
• Density: 1.155g/cm³
• Vapor Pressure: 0.000254mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE(50834-78-1)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE(50834-78-1)

Safety Data

• Hazardous Substances Data: 50834-78-1(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxy-phenyl)-2-methyl-thiazole is a chemical compound belonging to the class of organic molecules known as thiazoles. Thiazoles are heterocyclic compounds containing a five-member aromatic ring made up of one sulfur atom, one nitrogen atom, and three carbon atoms. These compounds usually have distinct odor or taste. The 4-methoxy-phenyl group attached to the 4th carbon of the thiazole ring adds further to its structural complexity. The methyl group on the 2nd carbon of the thiazole ring provides additional variation to the compound. This substance is often used in medicinal chemistry for drug discovery research. However, specific properties, toxicity levels, and applications for this particular compound may vary based on additional structural features or bonds.

InChI:InChI=1/C11H11NOS/c1-8-12-11(7-14-8)9-3-5-10(13-2)6-4-9/h3-7H,1-2H3

Upstream product

• 62-55-5 thioacetamide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 847267-17-8 thioacetimidic acid 2-(4-methoxyphenyl)-2-oxoethyl ester hydrobromide 
• 4136-21-4 p-methoxybenzoylmethanol 
• 119267-77-5 S-acetyl-2-mercapto-4’-methoxyacetophenone 
• 2475-92-5 4-methoxyacetophenone oxime 
• 108-24-7 acetic anhydride 

Downstream Products

• 94331-24-5 4-(4-methoxy-phenyl)-2-(4-nitro-styryl)-thiazole 
• 94905-22-3 4-(4-methoxy-phenyl)-2-styryl-thiazole 
• 50834-82-7 4-(4-methoxy-phenyl)-2-[4-(4-methoxy-phenyl)-2-methyl-2,5-dihydro-thiazol-2-ylmethyl]-thiazole 
• 30686-73-8 4-(4-hydroxyphenyl)-2-methylthiazole 
• 951122-77-3 5-bromo-2-(bromomethyl)-4-(4-methoxyphenyl)thiazole 
• 870521-07-6 5-bromo-4-(4-methoxyphenyl)-2-methylthiazole 
• 951120-52-8 3-[5-bromo-4-(4-methoxy-phenyl)-thiazol-2-ylmethoxy]-2,6-difluoro-benzamide 
• 951123-08-3 4-(4-methoxy-phenyl)-2-methyl-thiazole-5-carbonitrile 
• 951123-09-4 4-(4-methoxy-phenyl)-2-methyl-thiazole-5-carboxylic acid methyl ester 

Relevant articles and documents

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.

Lipase and deep eutectic mixture catalyzed efficient synthesis of thiazoles in water at room temperature

Lipase bio-catalyst or ammonium based deep eutectic mixture efficiently catalyzed aqueous phase synthesis of methyl-thiazole and amino-thiazole derivatives. The simple ammonium deep eutectic catalyst, easily synthesized from choline chloride and urea, is inexpensive, recyclable and bio-degradable, making it suitable for industrial applications. Springer Science+Business Media, LLC 2012.

Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners

A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl substituent. The structures of the synthesized compounds were confirmed by MS, 1H-NMR, and elemental analysis. In vitro antimicrobial activity for all the newly synthesized compounds at concentrations of 200-25 μg/mL was evaluated against Gram+ve organisms such as methicillin-resistant Staphylococcus aureus (MRSA), Gram-ve organisms such as Escherichia coli (E. coli), and the fungal strain Aspergillus niger (A. niger) by the cup plate method. Ofloxacin and ketoconazole (10 μg/mL) were used as reference standards for antibacterial and antifungal activity, respectively. Compounds 15, 16, and 20 showed notable antibacterial and antifungal activities at higher concentrations (200 μg/mL), whereas 17-19 were found to display significant antibacterial or antifungal activity (25-50 μg/mL) against the Gram+ve, Gram-ve bacteria, or fungal cells used in the present study.