50867-21-5

Basic information

• Product Name: Carbamimidic acid, N,N'-dicyclohexyl-, 1,1-dimethylethyl ester
• CAS NO: 50867-21-5
• Molecular Formula: C17H32N2O
• Molecular Weight: 280.454
• Mol File: 50867-21-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbamimidic acid, N,N'-dicyclohexyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamimidic acid, N,N'-dicyclohexyl-, 1,1-dimethylethyl ester(50867-21-5)
• EPA Substance Registry System: Carbamimidic acid, N,N'-dicyclohexyl-, 1,1-dimethylethyl ester(50867-21-5)

Safety Data

• Hazardous Substances Data: 50867-21-5(Hazardous Substances Data)

Upstream product

• 538-75-0 dicyclohexyl-carbodiimide 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 119595-73-2 L-α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))glutamate 
• 7439-10-3 tert-butyl 4-methylphenyl sulfide 
• 799267-32-6 tert-butyl (2S,5S)-6-azido-2-benzyloxycarbonylamino-5-hydroxyhexanoate 
• 860468-74-2 tert-butyl 2-(2-chloropyridin-4-yl)acetate 
• 87919-12-8 hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate 
• 87919-08-2 benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate 
• 87919-07-1 benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-ε-aminohexanoate 
• 87919-10-6 N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylic acid 
• 726173-65-5 tert-butyl (2S,5R)-6-azido-2-benzyloxycarbonylamino-5-hydroxyhexanoate 
• 87919-01-5 6',6''-di-tert-butyl-30-benzyl-18β-glycyrrhizin 
• 127291-01-4 benzyl 3β-(tert-butylglucuron-1'β-yl)-glycyrrhetate 
• 79385-60-7 NS-ditritylcysteine t-butyl ester 
• 1196872-66-8 tert butyl (4,5-dimethoxy-2-nitrophenyl)acetate 
• 510714-09-7 N-Cbz-(2S)-4,4-difluoroglutamic acid α-tert-butyl ester γ-glutamic acid α-tert-butyl γ-2-(trimethylsilyl)ethyl ester 

Relevant articles and documents

The synthesis of (2S)-4,4-difluoroglutamyl γ-peptides based on Garner's aldehyde and fluoro-reformatsky chemistry

The development of optically active fluorinated synthetic building blocks of general utility is a current goal of organo-fluorine chemists. The serine-derived Garner aldehyde was converted to a general 4,4-difluoroamino acid building block via fluoro-Reformatsky reaction with ethyl bromodifluoroacetate. The utility of this building block was demonstrated by the synthesis of derivatives of (2S)-4,4-difluoroglutamine, (2S)-4,4-difluoroglutamic acid, and its incorporation into a fluorophore-containing isopeptide 2 designed as a mechanistic probe of γ-glutamyl hydrolase. Compound 2 proved to be a substrate for γ-glutamyl hydrolase and was hydrolyzed at a rate significantly slower than the corresponding non-fluorinated analog.

Inhibitors of protein kinases

Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dependent kinase family and/or the glycogen synthase kinase 3 family and are useful in preventing and/or treating any type of pain, inflammatory disorders, cancer, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases, metabolic disorders, renal diseases, neurologic and neuropsychiatric diseases and neurodegenerative diseases.

Hydroxylysine containing glycoconjugates: An efficient synthesis of natural galactosylhydroxylysine (Gal-Hyl) and glucosylgalactosylhydroxylysine (Glu-Gal-Hyl) and of their (5S)-epimers

The paper reports the first chemical synthesis of α-d-glucopyranosyl- (1→2)-β-d-galactopyranosyl-5-O-hydroxylysine, a biological marker of bone resorption and of its unnatural (5S)-epimer, starting from commercial sugars and amino acids. Moreover, the synthetic protocol set-up has resulted in a new procedure for the synthesis of the β-d-galactopyranosyl-5-O- hydroxylysine and its unnatural (5S)-epimer.