509142-46-5

Basic information

• Product Name: N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine
• Synonyms: N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine
• CAS NO: 509142-46-5
• Molecular Weight: 285.392
• Mol File: 509142-46-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine(509142-46-5)
• EPA Substance Registry System: N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine(509142-46-5)

Safety Data

• Hazardous Substances Data: 509142-46-5(Hazardous Substances Data)

Upstream product

• 35691-16-8 2-chloro-N,N-dimethylquinazolin-4-amine 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 607-68-1 2,4-dichloroquinazoline 
• 509142-47-6 tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate 

Relevant articles and documents

Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1

The optimization of a series of 4-(dimethylamino)quinazoline antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. The combination of the elaboration of both the linker portion and the terminal phenyl ring provided N-(cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino} cyclohexyl)-3,4-difluorobenzamide hydrochloride 28 (ATC0175), which showed excellent antagonist activity at the MCH-R1 (IC50 = 3.4 nM) as well as good selectivity over the Y5 and the α2A receptors.