509142-47-6

Basic information

• Product Name: tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate
• Synonyms: tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate
• CAS NO: 509142-47-6
• Molecular Weight: 385.509
• Mol File: 509142-47-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate(509142-47-6)
• EPA Substance Registry System: tert-butyl (cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)carbamate(509142-47-6)

Safety Data

• Hazardous Substances Data: 509142-47-6(Hazardous Substances Data)

Upstream product

• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 607-68-1 2,4-dichloroquinazoline 
• 247570-24-7 tert-butyl N-[(1s,4s)-4-aminocyclohexyl]carbamate 
• 35691-16-8 2-chloro-N,N-dimethylquinazolin-4-amine 

Downstream Products

• 509142-46-5 N²-(cis-4-aminocyclohexyl)-N⁴,N⁴-dimethylquinazoline-2,4-diamine 

Relevant articles and documents

Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists

The optimization of the distance between two key pharmacophore features within our first hit compounds 1a and 2a led to the identification of a new class of potent non-peptidic antagonists for the MCH-R1, based around 4-amino-2-cyclohexylaminoquinazolines. In particular, ATC0065 (2c), N2-[cis-4-({2-[4-Bromo-2-(trifluoromethoxy)phenyl]ethyl}amino)cyclohexyl]-N4,N4-dimethylquinazoline-2,4-diamine dihydrochloride, bound with high affinity to the MCH-R1 (IC50 value of 16 nM) and showed good metabolic stability in liver microsomes from human and rat.