50916-31-9

Basic information

• Product Name: alpha-hydroxybenzeneacetyl chloride
• Synonyms: alpha-hydroxybenzeneacetyl chloride
• CAS NO: 50916-31-9
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59298
• EINECS: 256-845-2
• Mol File: 50916-31-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-hydroxybenzeneacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-hydroxybenzeneacetyl chloride(50916-31-9)
• EPA Substance Registry System: alpha-hydroxybenzeneacetyl chloride(50916-31-9)

Safety Data

• Hazardous Substances Data: 50916-31-9(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 611-71-2 MANDELIC ACID 

Downstream Products

• 58155-84-3 6,8-dibromo-2-(hydroxy-phenyl-methyl)-benzo[d][1,3]oxazin-4-one 
• 854621-70-8 C₃₀H₂₂N₂O₇S 
• 947155-91-1 N'-(2-hydroxy-2-phenylacetyl)-2-methyl-4,6-dihydroxybenzohydrazide 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 10606-73-2 ethyl 2-chloro-2-phenylacetate 
• 143314-51-6 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide 

Relevant articles and documents

The Direct Conversion of α-Hydroxyketones to Alkynes

Alkynes are highly important functional groups in organic chemistry, both as part of target structures and as versatile synthetic intermediates. In this study, a protocol for the direct conversion of α-hydroxyketones to alkynes is reported. In combination with the variety of synthetic methods that generate the required starting materials by forming the central C-C bond, it enables a highly versatile fragment coupling approach toward alkynes. A broad scope for this novel transformation is shown alongside mechanistic insights. Furthermore, the utility of our protocol is demonstrated through its application in concert with varied α-hydroxyketone syntheses, giving access to a broad spectrum of alkynes.