50998-74-8

Basic information

• Product Name: 2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester
• Synonyms: 2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester;Methyl 2-(p-toluenesulfonylamino)benzoate;2-(Toluene-4-Sulfonylamino)-Benzoic Acid Methyl Ester;2-(Toluene-4-Sulfonylamino)-Benzoic Acid Methyl Ester(WXC02960)
• CAS NO: 50998-74-8
• Molecular Formula: C₁₅H₁₅NO₄S
• Molecular Weight: 305.3489
• Mol File: 50998-74-8.mol
• Article Data: 28

Chemical Properties

• Melting Point: 115-116℃
• Boiling Point: 456.3°C at 760 mmHg
• Flash Point: 229.8°C
• Appearance: /
• Density: 1.31
• Vapor Pressure: 1.64E-08mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester(50998-74-8)
• EPA Substance Registry System: 2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester(50998-74-8)

Safety Data

• Hazardous Substances Data: 50998-74-8(Hazardous Substances Data)

Usage

General Description

2-[[(4-Methylphenyl)sulfonyl]amino]benzoic acid methyl ester is a chemical compound that belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid. Its molecular formula is C15H15NO4S. This particular chemical is commonly used in the field of synthetic organic chemistry as it plays a significant role in the preparation of various complex molecules for pharmaceuticals, materials, and other applications. Its properties, including solubility and reactivity, can differ substantially depending on factors such as pH, temperature, and the presence of other chemicals.

InChI:InChI=1/C15H15NO4S/c1-11-7-9-12(10-8-11)21(18,19)16-14-6-4-3-5-13(14)15(17)20-2/h3-10,16H,1-2H3

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 93-58-3 benzoic acid methyl ester 
• 941-55-9 4-toluenesulfonyl azide 
• 118-92-3 anthranilic acid 
• 606-27-9 methyl 2-nitrobenzoate 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 100627-39-2 N-(3-ethoxycarbonyl-propyl)-N-(toluene-4-sulfonyl)-anthranilic acid methyl ester 
• 105895-93-0 methyl 2-{(3-cyanopropyl)[(4-methylphenyl)sulfonyl]amino}benzoate 
• 152342-36-4 2-(N-Mesyl-2-methoxycarbonylanilino)-5-methoxy-1,4-benzoquinone 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 144632-82-6 N,N'-di-p-toluenesulphonyl-N,N'-di(2-methoxyphenyl)-1,3-diaminopropane 
• 23145-61-1 N-<3,4-Dimethoxy-benzyl>-N-p-toluolsulfonyl-anthranilsaeuremethylester 
• 23145-66-6 N-<4-Nitro-3-methoxy-benzyl>-N-p-toluolsulfonyl-anthranilsaeuremethylester 
• 23145-76-8 N-<3-Methoxy-benzyl>-N-p-toluolsulfonyl-anthranilsaeuremethylester 
• 298212-35-8 2-[(2-cyclopropylidene-ethyl)-(toluene-4-sulfonyl)-amino]-benzoic acid methyl ester 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 29489-04-1 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 
• 24310-36-9 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 68595-19-7 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile 

Relevant articles and documents

Iridium-Catalyzed Cycloisomerization of Alkynoic Acids: Synthesis of Unsaturated Lactones

The iridium-catalyzed cycloisomerization of various alkynoic acids was successfully developed, and a series of five-, six-, and especially seven-membered unsaturated lactones were constructed with moderate yields and excellent regioselectivities (up to 68

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism

Oxytocin (OT) and its receptor (OT-R) are implicated in the etiology of autism spectrum disorders (ASD), and OT-R is a potential target for therapeutic intervention. Very few nonpeptide oxytocin agonists have currently been reported. Their molecular and in vivo pharmacology remain to be clarified, and none of them has been shown to be efficient in improving social interaction in animal models relevant to ASD. In an attempt to rationalize the design of centrally active nonpeptide full agonists, we studied in a systematic way the structural determinants of the affinity and efficacy of representative ligands of the V1a and V2 vasopressin receptor subtypes (V1a-R and V2-R) and of the oxytocin receptor. Our results confirm the subtlety of the structure-affinity and structure-efficacy relationships around vasopressin/oxytocin receptor ligands and lead however to the first nonpeptide OT receptor agonist active in a mouse model of ASD after peripheral ip administration.

Visible Light Mediated Aryl Migration by Homolytic C?N Cleavage of Aryl Amines

The photocatalytic preparation of aminoalkylated heteroarenes from haloalkylamides via a 1,4-aryl migration from nitrogen to carbon, conceptually analogous to a radical Smiles rearrangement, is reported. This method enables the substitution of amino group