6590-65-4

Basic information

• Product Name: N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF&
• Synonyms: N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF&
• CAS NO: 6590-65-4
• Molecular Formula: C₁₄H₁₃NO₃S
• Molecular Weight: 275.327
• Mol File: 6590-65-4.mol
• Article Data: 75

Chemical Properties

• Melting Point: 203-205 °C
• Boiling Point: 445.1°C at 760 mmHg
• Flash Point: 223°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 4.05E-08mmHg at 25°C
• Refractive Index: 1.63
• PKA: 7.94±0.10(Predicted)
• CAS DataBase Reference: N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF&(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF&(6590-65-4)
• EPA Substance Registry System: N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF&(6590-65-4)

Safety Data

• Hazardous Substances Data: 6590-65-4(Hazardous Substances Data)

Usage

General Description

N-(2-Formylphenyl)-4-methyl-benzenesulfonamide is a chemical compound with the molecular formula C14H13NO2S. It is a sulfonamide derivative, which is a class of organic compounds that contain a sulfonyl functional group attached to an amino group. This specific compound is characterized by a benzene ring with a formyl group at the 2-position and a methyl group at the 4-position. Sulfonamides are commonly used as antimicrobial agents and in the synthesis of pharmaceutical drugs. The compound's properties and potential applications are further determined through research and testing in various chemical and biological studies.

InChI:InChI=1/C14H13NO3S/c1-11-6-8-13(9-7-11)19(17,18)15-14-5-3-2-4-12(14)10-16/h2-10,15H,1H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 529-23-7 o-aminobenzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 50998-74-8 methyl N-tosylanthranilate 
• 134-20-3 2-carbomethoxyaniline 
• 111881-64-2 (2-hydroxymethyl-phenyl)-carbamic acid benzyl ester 
• 118-92-3 anthranilic acid 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 552-89-6 2-nitro-benzaldehyde 
• 941-55-9 4-toluenesulfonyl azide 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 

Downstream Products

• 136117-42-5 N-(o-tosylaminobenzylidene)ethylamine 
• 122392-99-8 N-(o-tosylaminobenzylidene)methylamine 
• 6590-70-1 N-(o-tosylaminobenzylidene)benzylamine 
• 176214-83-8 o-tosylaminobenzaldehyde morpholinal 
• 182145-40-0 N-[2-(1-Hydroxyhept-6-enyl)phenyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Phosphine-catalyzed [4+1] annulation of 2-tosylaminochalcones with allenoates: Synthesis of trans-2,3-disubstitued indolines

Phosphine-catalyzed [4+1] annulation of 2-tosylaminochalcones with allenoates has been achieved, giving trans-2,3-disubstitued indolines as major diastereoisomers in moderate to good yields.

A new route to 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues through metal-free intramolecular azide-olefin oxidative cycloaddition

A collection of 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues was prepared by one pot azide substitution and intramolecular azide-olefin oxidative cycloaddition sequence under metal-free conditions.

Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils

A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.

Copper-Catalyzed (4+1) Cascade Annulation of Terminal Alkynes with 2-(Tosylmethyl)anilines: Synthesis of 2,3-Disubstituted Indoles

A novel strategy based on Cu-catalyzed (4+1) cascade annulation of terminal alkynes as one-carbon synthons with 2-(tosylmethyl)anilines has been developed for the expeditious synthesis of 2,3-disubstituted indoles, in which in situ generations of aza-o-quinone methides and alkynyl-copper(I) species are involved. This annulation provides an effective method for the assembly of synthetically and structurally interesting 2,3-disubstituted indoles.

Cascade Skeletal Rearrangement of Gold Carbene Intermediates: Synthesis of Medium-Sized Pyrimidine-Fused Benzolactones

A gold-catalyzed cyclization/cascade skeletal rearrangement of o-cyanophenylalkynones with 3-amino-benzo[d]-isoxazoles has been developed, which provides an approach for synthesizing medium-sized benzolactones. Based on the experimental results, we postul