51-64-9

Basic information

• Product Name: D-AMPHETAMINE HYDROCHLORIDE
• Synonyms: DEXTRO-AMPHETAMINE;D-AMPHETAMINE;D-AMPHETAMINE HYDROCHLORIDE;(aS)-a-Methyl-benzeneethanamine;d-a-Methylphenethylamine;DELTA-AMPHETAMINE;C07884;S(+)-Amphetamine, 1.0 mg/mL
• CAS NO: 51-64-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 171.67
• EINECS: 200-112-1
• Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 51-64-9.mol
• Article Data: 111

Chemical Properties

• Melting Point: 25°C
• Boiling Point: 208.93°C (estimate)
• Flash Point: 9℃
• Appearance: Colorless, oily liquid.
• Density: 0.9354 (estimate)
• Refractive Index: 1.5087 (estimate)
• Storage Temp.: ?20°C
• PKA: pKa 9.90 (Uncertain)
• CAS DataBase Reference: D-AMPHETAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: D-AMPHETAMINE HYDROCHLORIDE(51-64-9)
• EPA Substance Registry System: D-AMPHETAMINE HYDROCHLORIDE(51-64-9)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: 3249
• WGK Germany: 1
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 51-64-9(Hazardous Substances Data)

Usage

Description

D-AMPHETAMINE HYDROCHLORIDE, also known as D-Amphetamine Hydrochloride, is a 1-phenylpropan-2-amine with an S configuration. It is a more active isomer of Amphetamine and is classified as a controlled substance (stimulant). D-AMPHETAMINE HYDROCHLORIDE is known for its central nervous system (CNS) stimulating properties and anorexic effects. It works by inducing the release of catecholamines and serotonin, displacing the monoamines from their vesicular storage sites, and blocking catecholamine reuptake.

Uses

Used in Pharmaceutical Industry:
D-AMPHETAMINE HYDROCHLORIDE is used as a CNS stimulant for treating conditions such as attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an anorexic agent to suppress appetite, which can be beneficial for weight loss management.
Used in Research and Development:
D-AMPHETAMINE HYDROCHLORIDE is used as a research compound for studying the effects of stimulants on the central nervous system and their potential applications in various medical conditions.
Brand Names:
Some of the brand names for D-AMPHETAMINE HYDROCHLORIDE include Dexampex (Teva), Dexedrine (GlaxoSmithKline), Dextrostat (Shire), Ferndex (Ferndale), Adiparthrol, Afatin, Amfe-dyn, Amphaetex, Bipheramine, Curban, D-amfetasul, Dexadrine, Dexamed, Dexedrina, Dexten, Dextro-profetamine, Drinamyl, Durophet-m, Maxiton, Mephadexamine-r, Mephadexamin-r, Obetrol, Obotan, Proptan, Robese, Simpamina d, Steladex, Stil-2, and Synatan.

World Health Organization (WHO)

Schedule II of the 1971 Convention on Psychotropic Substances. See WHO comment for amfetamine. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries.

InChI:InChI=1/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1

Upstream product

• 17019-26-0 (E)-2-(hydroxyimino)-1-phenylpropan-1-one 
• 156-34-3 l-amphetamine 
• 5171-99-3 (1-phenylpropan-2-ylidene)hydrazine 
• 7499-19-6 2-methyl-2-phenylpropionamide 
• 10304-81-1 1-phenyl-2-chloropropane 
• 55-52-7 pheniprazine 
• 81136-08-5 2-methyl-3-phenylpropanoyl chloride 
• 14593-16-9 N-acetylamphetamine 
• 77287-34-4 formamide 
• 103-79-7 1-phenyl-acetone 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 98-71-5 4-hydrazino-benzenesulfonic acid 
• 540-69-2 ammonium formate 
• 705-60-2 (2-nitroprop-1-enyl)benzene 

Downstream Products

• 26393-84-0 bis-(2-hydroxy-ethyl)-(1-methyl-2-phenyl-ethyl)-amine 
• 63918-85-4 2-(1-methyl-2-phenyl-ethylamino)-ethanol 
• 20640-10-2 N-(1-Methyl-2-phenyl-ethyl)-β-mercapto-ethylamin 
• 108303-14-6 N-(1-methyl-2-phenyl-ethyl)-ethylenediamine 
• 4663-88-1 ((S)-1-methyl-2-phenyl-ethyl)-carbamic acid-(2-hydroxy-ethyl ester) 
• 105340-05-4 1-(1-methyl-2-phenyl-ethyl)-imidazolidin-2-one 
• 13033-48-2 N-((S)-1-methyl-2-phenyl-ethyl)-succinamic acid 
• 139-68-4 (+/-)-nicotinic acid-(1-methyl-2-phenyl-ethylamide) 
• 15855-02-4 N-α-Methylphenethyl-n-pyridincarboxamid 
• 101584-03-6 phenylsulfanyl-acetic acid-((S)-1-methyl-2-phenyl-ethylamide) 
• 40188-04-3 N-((S)-1-methyl-2-phenyl-ethyl)-furan-2-carboxamide 
• 40302-91-8 (+/-)-N-(1-methyl-2-phenyl-ethyl)-furan-2-carboxamide 
• 100710-59-6 N-((S)-1-methyl-2-phenyl-ethyl)-thiophene-2-carboxamide 
• 100710-59-6 (+/-)-N-(1-methyl-2-phenyl-ethyl)-thiophene-2-carboxamide 

Relevant articles and documents

Rapid Synthesis of Primary Amines from Ketones using Choline Chloride/Urea Deep Eutectic as a Reaction Medium

-

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND

The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBN E3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBN E3 ubiquitin ligase.