51230-16-1

Basic information

• Product Name: 2-methoxy-4-nitro-1-phenoxy-benzene
• Synonyms: 2-methoxy-4-nitro-1-phenoxy-benzene
• CAS NO: 51230-16-1
• Molecular Weight: 245.235
• Mol File: 51230-16-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methoxy-4-nitro-1-phenoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-4-nitro-1-phenoxy-benzene(51230-16-1)
• EPA Substance Registry System: 2-methoxy-4-nitro-1-phenoxy-benzene(51230-16-1)

Safety Data

• Hazardous Substances Data: 51230-16-1(Hazardous Substances Data)

Upstream product

• 1009-36-5 2-chloro-5-nitroanisole 
• 108-95-2 phenol 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 52427-05-1 2-bromo-5-nitrophenol 
• 1695-04-1 2-methoxyphenyl phenyl ether 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 100-67-4 potassium phenolate 
• 5458-84-4 2-iodo-5-nitroanisole 

Downstream Products

• 287192-77-2 5-amino-2-phenoxyphenol 
• 857620-64-5 acetic acid-(5-methoxy-2-nitro-4-phenoxy-anilide) 
• 857590-98-8 5-methoxy-2-nitro-4-phenoxy-aniline 
• 857620-62-3 acetic acid-(3-methoxy-4-phenoxy-anilide) 
• 14064-93-8 1-methoxy-2-phenoxy-4-nitrobenzene 
• 70995-08-3 Phenyl-(5-nitro-2-hydroxy-phenyl)-aether 
• 60433-63-8 5-nitro-2-phenoxyphenol 
• 733729-21-0 3-methoxy-4-phenoxy-phenylamine 
• 118450-89-8 N-(2-methoxy-4-nitrophenyl)piperidine 

Relevant articles and documents

Indole compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses an indole compound as well as a preparation method, a pharmaceutical composition and an application thereof. Specifically, the invention relates to an indole derivative as shown in a general formula I and a medicinal salt thereof, a preparation method of the indole derivative, a composition containing one or more compounds, and applications of the compounds in preparation of medicines for preventing and/or treating diseases related to IDO1 and/or TDO.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

The Smiles Rearrangement of 2-Aryloxy-5-nitrophenoxides. Attempted Routes to Benzoxirens and Tribenzotrioxonins

Formation of dibenzo-p-dioxins by the pyrolysis of 2-halogenophenoxides does not appear to involve intermediate benzoxirens.Thermal self-condensation to potassium 2-bromo-5-nitrophenoxide (1b) gave a mixture of 2,7- and 2,8-dinitrobenzo-p-dioxins (6d) and (6e).The mechanism of formation of the 2,8-isomer (6e) is shown to involve Smiles rearrangement of potassium 2-(2-bromo-5-nitrophenoxy)-5-nitrophenoxide (9a).Further examples of Smiles rearrangements of 2-aryloxy-5-nitrophenoxides and an attempted synthesis of the tribenzotrioxonin derivatives (16) are described.