5131-58-8 Usage
Description
4-Nitro-1,3-phenylenediamine is an organic compound that exists as orange prisms with blue luster or a yellow crystalline solid. It is a chemical reagent with significant applications in the pharmaceutical industry due to its chemical properties as a yellow crystal powder.
Uses
Used in Pharmaceutical Synthesis:
4-Nitro-1,3-phenylenediamine is used as a chemical reagent for the synthesis of various pharmaceuticals, particularly in the development of potent and selective Chk-1 inhibitors. These inhibitors play a crucial role in the treatment of different types of cancers, making this compound an essential component in the fight against the disease.
Used in Cancer Treatment:
In the field of oncology, 4-Nitro-1,3-phenylenediamine is utilized in the synthesis of Chk-1 inhibitors, which are vital for the treatment of various cancers. These inhibitors target specific proteins involved in cell cycle regulation, thereby preventing the uncontrolled growth of cancer cells and offering a potential therapeutic approach to cancer treatment.
Used in Chemical Research:
As a general chemical reagent, 4-Nitro-1,3-phenylenediamine also finds application in chemical research and development. Its unique properties allow it to be used in various experimental setups, contributing to the advancement of knowledge in the field of chemistry and related disciplines.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Nitro-1,3-phenylenediamine is an amine/organonitrate. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data for 4-Nitro-1,3-phenylenediamine are not available, but 4-Nitro-1,3-phenylenediamine is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 5131-58-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,3 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5131-58:
(6*5)+(5*1)+(4*3)+(3*1)+(2*5)+(1*8)=68
68 % 10 = 8
So 5131-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N3O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,7-8H2
5131-58-8Relevant articles and documents
Method of producing 4-nitro-m-phenylenediamine sulfate
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, (2008/06/13)
A method of manufacture of 4-nitro-m-phenylenediamine sulfate is taught. The resultant compound is useful in the dyeing of keratinic fibers, particularly, human hair. It exhibits reduced toxicity and potential for damage to such fibers, and is easier to remove than are other known compounds.
Possible Anthelmintic Agents: Syntheses of Various Imidazoquinazolinone Carbamates
Kumar, Shiv,Kansal, V. K.,Bhaduri, A. P.
, p. 1068 - 1071 (2007/10/02)
Two of the three possible imidazoquinazolinone-2-carbamates representing angular and linear heterocyclic systems, have been synthesised and evaluated for their anthelmintic activity.During the course of the synthesis of ethyl or methyl 7-alkylimidazoquinazolin-8-one-2-carbamate, it is observed that the reaction of 3-alkyl-7-chloro-6-nitroquinazolin-4-ones with butanol saturated with aq.NH3, furnishes a number of ring-opened products which have been characterised on the basis of elemental analyses, IR, PMR and mass spectral data.The same reaction when carried out with dry NH3, furnishes the desired amino-nitro derivatives.UV and IR spectra of the linear and angular imidazoquinazolinones have also been compared.