51331-98-7

Basic information

• Product Name: C₁₆H₁₄O
• Synonyms: C₁₆H₁₄O
• CAS NO: 51331-98-7
• Molecular Weight: 222.287
• Mol File: 51331-98-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄O(51331-98-7)
• EPA Substance Registry System: C₁₆H₁₄O(51331-98-7)

Safety Data

• Hazardous Substances Data: 51331-98-7(Hazardous Substances Data)

Upstream product

• 16188-57-1 2-iodo-4-methylphenol 
• 40888-14-0 2-methyl-4-(2-methylphenyl)-3-butyn-2-ol 
• 18441-43-5 5-methylbenzofuran 
• 95-49-8 2-methylchlorobenzene 

Relevant articles and documents

N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex Catalyzed Direct C-H Bond Arylation of Benzo[b]furans with Aryl Chlorides

The first example of sole direct C-H bond arylation of benzo[b]furans with aryl chlorides was achieved catalyzed by a well-defined NHC-Pd(II)-Im complex. Under the suitable conditions, all reactions involving kinds of benzo[b]furans and (hetero)aryl chlor

Simple, convenient, and efficient synthesis of 2-aryl-substituted benzo[b]furans

A simple, convenient, and efficient one-pot method for the preparation of benzofuran is reported. Sonogashira coupling reaction of aryl iodides with 2-methyl-3-butyn-2-ol was used as an acetylene source in the presence of Pd(PPh3)2Cl2 and CuI. Deprotection of the acetylene moiety in the same pot using a strong base and the second Sonogashira coupling/cyclization of and substituted o-iodophenols led to the formation of the appropriate benzo[b]furans. These protocols also can be used in the synthesis of natural products and indoles. Copyright Taylor & Francis Group, LLC.