40888-14-0

Basic information

• Product Name: 2-Methyl-4-o-tolylbut-3-yn-2-ol
• Synonyms: 2-Methyl-4-o-tolylbut-3-yn-2-ol;2-Methyl-4-(2-methylphenyl)-3-butyn-2-ol
• CAS NO: 40888-14-0
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• Mol File: 40888-14-0.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-4-o-tolylbut-3-yn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-o-tolylbut-3-yn-2-ol(40888-14-0)
• EPA Substance Registry System: 2-Methyl-4-o-tolylbut-3-yn-2-ol(40888-14-0)

Safety Data

• Hazardous Substances Data: 40888-14-0(Hazardous Substances Data)

Usage

General Description

2-Methyl-4-o-tolylbut-3-yn-2-ol, also known as 4-(2-Methyl-1-propyn-1-yl)toluene, is a chemical compound with the molecular formula C11H14O. It is a white crystalline solid that is commonly used in the synthesis of pharmaceuticals and organic compounds. The compound is a tertiary alcohol with a triple bond at the third carbon and a phenyl group at the fourth carbon. It is also utilized as a reagent in organic chemistry reactions, such as in the formation of carbon-carbon triple bonds. The compound is flammable and should be handled with care due to its potential hazards to human health and the environment.

Upstream product

• 40888-06-0 1-[3-(1-Ethoxy-ethoxy)-3-methyl-but-1-ynyl]-2-methyl-benzene 
• 95-46-5 2-methylphenyl bromide 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 29552-15-6 4-chloro-2-methylbut-3-yn-2-ol 
• 615-37-2 ortho-methylphenyl iodide 
• 1232660-55-7 o-tolyl 1H-imidazole-1-sulfonate 
• 766-47-2 1-ethynyl-2-methylbenzene 
• 67-64-1 acetone 

Downstream Products

• 917507-03-0 (3Z)-2-methyl-4-(2-methylphenyl)-3-buten-2-ol 
• 917507-05-2 (3E)-2-methyl-4-(2-methylphenyl)-3-buten-2-ol 
• 349668-00-4 (3Z)-2-methoxy-2-methyl-4-(2-methylphenyl)-3-butene 
• 917507-06-3 (3E)-2-methoxy-2-methyl-4-(2-methylphenyl)-3-butene 
• 51331-98-7 C₁₆H₁₄O 
• 59105-21-4 1-methoxy-4-(2-(2-tolyl)ethynyl)benzene 

Relevant articles and documents

Bimetal Cooperatively Catalyzed Arylalkynylation of Alkynylsilanes

An unprecedented Pd/Rh cooperatively catalyzed arylalkynylation of alkynylsilanes was developed to merge an alkynylidene moiety with benzosilacycle. These silaarenes possess a particular aggregation-induced emission behavior. Mechanistic investigations demonstrate that the relay trimetallic transmetalation plays a pivotal role in governing this transformation.

Rhodium-Catalyzed Annulation of Phenacyl Ammonium Salts with Propargylic Alcohols via a Sequential Dual C-H and a C-C Bond Activation: Modular Entry to Diverse Isochromenones

Given their omnipresence in natural products and pharmaceuticals, isochromenone congeners are one of the most privileged scaffolds to synthetic chemists. Disclosed herein is a dual (ortho/meta) C-H and C-C activation of phenacyl ammonium salts (acylammonium as traceless directing group) toward annulation with propargylic alcohols to accomplish rapid access for novel isochromenones by means of rhodium catalysis from readily available starting materials. This operationally simple protocol features broad substrate scope and wide functional group tolerance. Importantly, the protocol circumvents the need of any stoichiometric metal oxidants and proceeds under aerobic conditions.

DBU-promoted carbonylative synthesis of 1,3-oxathiolan-2-ones from propargylic alcohols with TFBen as the CO source

A DBU-promoted carbonylative cyclization of propargylic alcohols with sulfur was developed. Various 1,3-oxathiolan-2-ones were produced in 61-98% yields under mild conditions in the absence of metal catalysts. TFBen (benzene-1,3,5-triyl triformate) as an efficient and solid CO surrogate and S8 as an ideal sulfur source were employed and incorporated.