51366-39-3Relevant articles and documents
Structural investigations of 3-acetamido-4-nitrobenzal derivatives
Rusek,Bryndal,Picur,Lis,Brzostowska
, p. 241 - 257 (2001)
N-(p-dimethylaminophenyl)-α-(3acetamido-4-nitrophenyl)nitrone (I) and 3-acetamido-4-nitrobenzylpyridinium bromide (II) were synthesized and their crystal structures were determined by X-ray diffraction methods. The geometry of carbon-nitrogen bond in nitrone is trans. In I the acetamido moiety slightly deviates from plane to the rest of molecule. The intramolecular N-H···O and C-H···O as well as intermolecular C-H···O hydrogen bonds stabilize the crystal structures of both the compounds. NMR investigations of II have given spectra with extra signals in comparison to the number of expected that suggests that dominating structure of this compound observed in crystal state coexists in solution with comparable amount of the additional form due to an interaction with solvent and increasing conformational freedom. For II duplication of signal number is observed for the 3-acetamido-4-nitrobenzyl substituent due to formation only of two different edge to face structures of this compound in DMSO and D2O solution. For I in DMSO solution the major form has perpendiculair orientation of N,N-dimethylaniline substituent on nitrone bond against the plane containing the rest of the molecule.
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Cohen,Dakin
, p. 331 (1903)
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COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF
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Paragraph 364-366, (2019/08/29)
The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.
Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride
Lu, Yang,Li, Yaming,Zhang, Rong,Jin, Kun,Duan, Chunying
supporting information, p. 9422 - 9427 (2013/10/08)
An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions.
