65745-70-2Relevant articles and documents
Selective ortho methylation of nitroheteroaryls by vicarious nucleophilic substitution
Achmatowicz, Michal,Thiel, Oliver R.,Gorins, Gilles,Goldstein, Corinne,Affouard, Caroline,Jensen, Randy,Larsen, Robert D.
, p. 6793 - 6799 (2008/12/22)
(Chemical Equation Presented) An efficient and scalable three-step one-pot approach to 6-methyl-5-nitroisoquinoline (1) from inexpensive 5-nitroisoquinoline, utilizing the vicarious nucleophilic substitution (VNS) as a key step, is described. The optimized reaction conditions can be applied to a limited number of other aromatic and heteroaromatic nitro compounds. Attempts to understand the observed selectivity in the VNS step led to the discovery of two new reaction pathways under VNS conditions, one leading to an isoxazole and the other resulting in the formal cyclopropanation of an aromatic nitro compound.
Reactivity of Nitroarenes towards Grignard Reagents; General Synthesis of Alkyl-Chloro Compounds in Aromatic Bicyclic Systems
Bartoli, Giuseppe,Bosco, Marcella
, p. 616 - 617 (2007/10/02)
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