515141-51-2 Usage
Description
GW 803430 is a compound that functions as a melanin-concentrating hormone receptor 1 (MCH1) antagonist. It is designed to target and block the MCH1 receptor, which is involved in regulating various physiological processes, including appetite, stress response, and mood regulation.
Uses
Used in Pharmaceutical Industry:
GW 803430 is used as an MCH1 antagonist for the treatment of obesity. By blocking the MCH1 receptor, it can help reduce appetite and promote weight loss, making it a potential therapeutic option for individuals struggling with obesity.
GW 803430 is also used as an MCH1 antagonist for the treatment of depression. The MCH1 receptor has been implicated in mood regulation, and blocking this receptor may help alleviate depressive symptoms and improve overall mental health.
Biochem/physiol Actions
GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice. It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 515141-51-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,5,1,4 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 515141-51:
(8*5)+(7*1)+(6*5)+(5*1)+(4*4)+(3*1)+(2*5)+(1*1)=112
112 % 10 = 2
So 515141-51-2 is a valid CAS Registry Number.
515141-51-2Relevant articles and documents
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists
Hertzog, Donald L.,Al-Barazanji, Kamal A.,Bigham, Eric C.,Bishop, Michael J.,Britt, Christy S.,Carlton, David L.,Cooper, Joel P.,Daniels, Alex J.,Garrido, Dulce M.,Goetz, Aaron S.,Grizzle, Mary K.,Guo, Yu C.,Handlon, Anthony L.,Ignar, Diane M.,Morgan, Ronda O.,Peat, Andrew J.,Tavares, Francis X.,Zhou, Huiqiang
, p. 4723 - 4727 (2007/10/03)
Optimization of a series of constrained melanin-concentrating hormone receptor 1 (MCH R1) antagonists has provided compounds with potent and selective MCH R1 activity. Details of the optimization process are provided and the use of one of the compounds in