51556-09-3

Basic information

• Product Name: Benzene, 1-bromo-4-(chloroethynyl)-
• CAS NO: 51556-09-3
• Molecular Formula: C8H4BrCl
• Molecular Weight: 215.477
• Mol File: 51556-09-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(chloroethynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(chloroethynyl)-(51556-09-3)
• EPA Substance Registry System: Benzene, 1-bromo-4-(chloroethynyl)-(51556-09-3)

Safety Data

• Hazardous Substances Data: 51556-09-3(Hazardous Substances Data)

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 16116-78-2 (4-bromophenyl)(trimethylsilyl)acetylene 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 64-19-7 acetic acid 

Downstream Products

• 1638667-44-3 (Z)-5-(3-(4-bromophenyl)-2,3-dichloroallyl)dihydrofuran-2(3H)-one 
• 1029431-48-8 (R)-1-(4-bromophenyl)-2-chloroethanol 
• 1076233-87-8 (S)-1-(4-bromophenyl)-2-chloroethan-1-ol 
• 1322084-35-4 1-bromo-4-(ethoxyethynyl)benzene 

Relevant articles and documents

Transition-Metal-Free One-Step Synthesis of Ynamides

A robust transition-metal-free one-step strategy for the synthesis of ynamides from sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides is presented. This method is not only effective for internal ynamides but also amenable for terminal ynamides. Various functional groups, even the vinyl moiety, are compatible, and thus, this strategy offers the opportunity for further functionalization.

Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes

The [2+2] cycloaddition is a versatile strategy for the synthesis of strained cyclobutenes of high synthetic value. In this study, two efficient intermolecular [2+2] cycloadditions between two different types of chloroalkynes and unactivated alkene are realized with gold catalysis. Of significance is that the reaction works with challenging monosubstituted unactivated alkenes, which is unprecedented in gold catalysis and scarcely documented in other metal-catalyzed/promoted reactions; moreover, the reaction exhibits excellent regioselectivities, which are much better than those reported in literature. With 1,2-disubstituted unactivated alkenes, the reaction is largely stereospecific. The cyclobutene products can be prepared in nearly gram scale and readily undergo further reactions including various cross-coupling reactions using the C(sp2)-Cl and/or C(sp2)-SPh bond, which in turn substantially broaden the scope of accessible cyclobutenes and enhance the synthetic utility of this bimolecular reaction.

A copper (II) (II) composite chlorinating agent and copper-based composite chlorinating agent synthesis of 1-chloro-2-aryl acetylene method

The invention discloses a copper (II) composite chlorinating agent and a method for synthesizing 1-chlorine-2-aryl acetylene based on the copper (II) composite chlorinating agent. The structural formula of the copper (II) composite chlorinating agent is CuCl2.xNaCl.yAl2O3. The chlorinating agent is applicable to chlorination of various substituted aryl acetylene substrates, and is high in universality; the chlorinating agent can directly carry out chlorination reaction on aryl acetylene so as to obtain a 1-chlorine-2-aryl acetylene product; the method is mild in reaction condition, 1-chlorine-2-aryl acetylene can be synthesized with high yield and high selectivity, and the production cost of the 1-chlorine-2-aryl acetylene derivative is greatly lowered.