51591-89-0 Usage
Description
[S(R,R)]-2-amino-1-[p-(methylsulphonyl)phenyl]propane-1,3-diol, commonly known as amifostine, is a chemoprotective agent that serves as a prodrug activated by alkaline phosphatase in the body. It is characterized by its ability to scavenge free radicals and shield healthy cells from the damaging effects of chemotherapy. Amifostine is recognized for its potential to mitigate the risk of side effects, such as kidney and nerve damage, associated with certain cancer treatments.
Uses
Used in Cancer Treatment:
Amifostine is utilized as a chemoprotective agent for cancer patients undergoing specific types of chemotherapy. It is particularly effective in reducing the toxic effects of certain chemotherapy drugs on normal tissues, thereby lowering the risk of side effects like kidney damage and nerve damage. Amifostine is typically administered by injection before the commencement of chemotherapy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, amifostine is used as an active pharmaceutical ingredient in the formulation of medications aimed at providing protection to healthy cells during cancer treatment. Its role in mitigating the side effects of chemotherapy makes it a valuable component in the development of supportive care pharmaceuticals for cancer patients.
Used in Clinical Research:
Amifostine is also employed in clinical research as a subject of study for its potential applications in reducing the harmful effects of chemotherapy on normal tissues. Researchers investigate its mechanisms of action, efficacy, and safety profile to further understand its role in cancer treatment and explore possible enhancements to its chemoprotective properties.
Check Digit Verification of cas no
The CAS Registry Mumber 51591-89-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,9 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 51591-89:
(7*5)+(6*1)+(5*5)+(4*9)+(3*1)+(2*8)+(1*9)=130
130 % 10 = 0
So 51591-89-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO4S/c1-16(14,15)8-4-2-7(3-5-8)10(13)9(11)6-12/h2-5,9-10,12-13H,6,11H2,1H3
51591-89-0Relevant articles and documents
Preparation method of florfenicol
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Paragraph 0019; 0027, (2017/08/25)
The invention relates to a preparation method of florfenicol, which belongs to the technical field of medicine synthesis. The preparation method adopts D-p-methylsulfonyl-phenylserine ethyl ester as a raw material to be subjected to reducing reaction, cyclization reaction, fluoridation and hydrolytic reaction to prepare the florfenicol. In the fluoridation, dichloromethane is used as a solvent, a cyclization product and a fluoridation reagent are used as reaction raw materials, and the mass ratio of the cyclization product to the fluoridation reagent is (1.25 to 1.30) to 1. The preparation method has the advantages of simple process operation and low cost. By controlling a reaction condition and using additives, byproducts of the fluoridation are reduced, so that a florfenicol product with high purity and fewer impurities can be obtained only by virtue of one-step decoloration and refining step, the product cost can be controlled, and the production efficiency can be improved.
CYCLOFUNCTIONALISATION REACTIONS OF EPOXYALCOHOL DERIVATIVES. 3. CYCLISATION-ACYL MIGRATION OF N-BENZOYLCARBAMATES TO STEREODEFINED OXAZOLIDINONES. A NEW, DIASTEREOSPECIFIC ROUTE TO THIAMPHENICOL.
McCombie, S. W.,Nagabhushan, T. L.
, p. 5395 - 5398 (2007/10/02)
N-Benzoylcarbamates formed in situ from 2,3-epoxyalcohols and PhCONCO undergo clean to C-2 cyclisation followed by N to O acyl migration on treatment with catalytic sodium imidazolide or other bases.Subsequent benzoate cleavage (NaOMe) is accompanied by equilibration of the N-unsubstituted oxazolidinones; cleavage without significant isomerisation is achieved with MeLi or Zn(BH4)2.This methodology is applied in a diastereospecific, 6-step conversion of methyl 4-bromophenyl sulfonate to racemic Thiamphenicol.