516-85-8 Usage
Uses
Different sources of media describe the Uses of 516-85-8 differently. You can refer to the following data:
1. Dehydroergosterol (DHE) is suitable for the transfer of DHE from a population of donor (LD) to acceptor (LA) liposomes.
2. A fluorescent cholesterol analog useful as a probe in membrane research.
Definition
ChEBI: A phytosterol consiting of ergostane having double bonds at the 5,6-, 7,8- 9,11- and 22,23-positions as well as a 3beta-hydroxy group.
General Description
Dehydroergosterol (DHE) is a fluorescent sterol that possesses similar biophysical properties as cholesterol. It is found in yeast cells and other fungi.
Biochem/physiol Actions
Dehydroergosterol (DHE) is used for the visualization of intracellular traffic and intracellular transport kinetics.
Check Digit Verification of cas no
The CAS Registry Mumber 516-85-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 516-85:
(5*5)+(4*1)+(3*6)+(2*8)+(1*5)=68
68 % 10 = 8
So 516-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1
516-85-8Relevant articles and documents
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Delseth,C. et al.
, p. 2037 - 2045 (1979)
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Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and e
Li, Xinghui,Zhang, Zeliang,Fan, Huafang,Miao, Yinlong,Tian, Hailong,Gu, Yucheng,Gui, Jinghan
, p. 4886 - 4890 (2021)
Pinnigorgiols B and E are 9,11-secosteroids with a unique tricyclic γ-diketone framework. Herein, we report the first synthesis of these natural products from inexpensive, commercially available ergosterol. This synthesis features a semipinacol rearrangem
Synthesis of 9,11-Secosteroids Pinnisterol E, Glaciasterol B, and 6-Keto-aplidiasterol B
Fan, Huafang,Gui, Jinghan,Li, Xinghui,Miao, Yinlong,Zhang, Mengqing
supporting information, p. 1684 - 1688 (2022/03/14)
A 10-step gram-scale synthesis of 9,11-secosteroid pinnisterol E from the inexpensive ergosterol is reported. This synthesis features a series of highly selective redox transformations such as regioselective olefin hydrogenation (PtO2), acid-sensitive endoperoxide reduction (Al-Ni alloy, Zn), and regio- and diastereoselective dienone oxidation. The robustness of this strategy is clearly demonstrated through the formal synthesis of 11(9 → 7)abeo-steroid pleurocin B and the divergent synthesis of 9,11-secosteroids glaciasterol B and 6-keto-aplidiasterol B from the inexpensive cholesterol.
