5171-37-9 Usage
Description
UNCARINE E is an alkaloid extract derived from the Uncaria genus, specifically Uncaria tomentosa, which is known for its potential antiproliferative and pro-apoptotic effects. This alkaloid is found in several species of the Uncaria plant and forms colorless crystals when extracted with methanol. UNCARINE E exhibits a laevorotatory optical rotation with a specific rotation value of [α]D 96° (CHCI3). Its molecular structure has been determined through the use of various spectroscopic methods.
Uses
Used in Pharmaceutical Applications:
UNCARINE E is used as a bioactive compound for its potential antiproliferative and pro-apoptotic effects. These properties make it a promising candidate for the development of new drugs and therapies targeting various diseases, particularly cancer.
Used in Research and Development:
As a bioactive alkaloid, UNCARINE E is utilized in research and development for the study of its chemical properties, potential interactions with biological systems, and its role in the development of novel therapeutic agents.
Used in Traditional Medicine:
UNCARINE E, being derived from the Uncaria tomentosa plant, is also used in traditional medicine practices, where the plant is believed to possess various healing properties. The alkaloid may contribute to these therapeutic effects and be used in the preparation of traditional remedies.
Used in Drug Delivery Systems:
Similar to gallotannin, UNCARINE E could potentially be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. This application would require further research and development to optimize the delivery methods and ensure the safety and efficacy of the compound.
References
Hart, Johns, Lamberton., Chem. Commun., 87 (1967)
Hemingway, Phillipson., 1. Pharm. Pharmacol., 24, 169P (1972)
Check Digit Verification of cas no
The CAS Registry Mumber 5171-37-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,7 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5171-37:
(6*5)+(5*1)+(4*7)+(3*1)+(2*3)+(1*7)=79
79 % 10 = 9
So 5171-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H24N2O4/c1-12-14-10-23-8-7-21(16-5-3-4-6-17(16)22-20(21)25)18(23)9-13(14)15(11-27-12)19(24)26-2/h3-6,11-14,18H,7-10H2,1-2H3,(H,22,25)/t12-,13-,14-,18?,21?/m1/s1
5171-37-9Relevant articles and documents
Analysis of the kinetics of isomerization of spiro oxindole alkaloids
Laus, Gerhard,Broessner, Dagmar,Senn, Gilbert,Wurst, Klaus
, p. 1931 - 1936 (2007/10/03)
The isomerization of the spiro oxindole alkaloids mitraphylline, isomitraphylline, pteropodine, isopteropodine, speciophylline and uncarine F in water has been studied at several temperatures and the rate coefficients have been determined. The effect of pH on the rate of reaction and the equilibrium composition has been investigated. The rate coefficients in water and in organic solvents correlate satisfactorily with the Dimroth-Reichardt solvent polarity parameter. The present results support the existence of a zwitterionic intermediate stabilized by polar solvents and show that protonation of the alkaloids inhibits the isomerization. The crystal structure of pteropodine has been determined.
Transformation of indole alkaloids. I. Conversion of oxindole alkaloids into indole alkaloids
Aimi,Yamanaka,Endo,et al.
, p. 2015 - 2021 (2007/10/04)
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Yohimbane derivatives. 3. The oxidative rearrangement of indole alkaloids to their spirooxindole analogs.
Zinnes,Shavel Jr.
, p. 1765 - 1771 (2007/11/06)
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