51771-31-4Relevant articles and documents
Antimicrobial Activity of N-(3-Chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide Derivatives
Alghamdi, Saad,Almehmadi, Mazen M.,Asif, Mohammad
, p. 91 - 95 (2022/03/27)
A series of N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide derivatives (4a-g) were synthesized by reacting various N’-arylidene-4-nitro benzo hydrazide (3a-g) with chloro acetyl chloride in the presence of triethylamine and dioxane. Infrared (IR), proton nuclear magnetic resonance (1HNMR), and mass (MS) spectrometric techniques were used to describe the structure of synthesized compounds, which were further tested for in vitro antibacterial activity, and benzylpenicillin was used as a reference drug. Compounds (4b) and (4e) were showed high antibacterial action, whereas the remaining compounds (4a, 4c, 4d, 4f, and 4g) were showed moderate activity. Finally, this research demonstrates the design and development of novel antibacterial agents.
Lewis acid-mediated nucleophilic addition of dialkylphosphite to C=N double bond of hydrazones
Lien, Chia-Ling,Yeh, Shu-Hua,Hsu, Chi-Tung
experimental part, p. 543 - 549 (2009/11/30)
The synthesis of new phenyl substituted derivatives (2) of -hydrazino-alkylphosphonic acids by Lewis acid-mediated addition of dialkylphosphite to hydrazones, derived from benzoylhydrazines and benzaldehydes, is described. Reactions were successfully prom
