51827-14-6Relevant articles and documents
MALT1 INHIBITORS AND USES THEREOF
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Paragraph 00324; 00325; 00328, (2019/08/15)
Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis,an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
Expeditious amide-forming reactions using thiol esters
Kurosu, Michio
, p. 591 - 594 (2007/10/03)
The reaction of a 2-pyridylthiol ester with a dimethylaluminum amide leads to the rapid formation of the corresponding amide. The tolylthiol esters can be activated with silver trifluoroacetate and coupled even with poorly reactive amino compounds. (C) 20
Peptidyl α-Ketoheterocyclic Inhibitors of Human Neutrophil Elastase. 2. Effect of Varying the Heterocyclic Ring on in Vitro Potency
Edwards, Philip D.,Wolanin, Donald J.,Andisik, Donald W.,Davis, Watthew W.
, p. 76 - 85 (2007/10/02)
A series of peptidyl α-ketoheterocycles were synthesized and evaluated for their in vitro inhibition of human neutrophil elastase (HNE).Several heterocycles, including oxazoline and benzoxazole, afforded extremely potent inhibitors of HNE (1p-r) with nano
