54647-77-7 Usage
Description
CBZ-L-VALINE DCHA, also known as Carbobenzyloxy-L-valine dicyclohexylammonium, is a chemical compound derived from valine, an essential amino acid. It is characterized by its carbobenzyloxy group and dicyclohexylammonium salt, which contribute to its unique properties and applications in the pharmaceutical industry.
Used in Pharmaceutical Industry:
CBZ-L-VALINE DCHA is used as a building block for the synthesis of peptides and proteins, playing a crucial role in the development and production of diverse pharmaceutical products.
CBZ-L-VALINE DCHA is used as a protecting group for the amino acid side chains during peptide synthesis, which helps to control the specificity and selectivity of the reactions, ensuring the correct formation of peptide bonds and preventing unwanted side reactions.
CBZ-L-VALINE DCHA is also utilized in the preparation of various pharmaceuticals and biologically active molecules due to its ability to serve as a chiral auxiliary, providing a source of enantioselectivity and enhancing the efficiency of asymmetric synthesis processes.
Overall, CBZ-L-VALINE DCHA is an important compound in the pharmaceutical industry, contributing to the synthesis and development of a wide range of therapeutic agents and biologically active molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 54647-77-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,6,4 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 54647-77:
(7*5)+(6*4)+(5*6)+(4*4)+(3*7)+(2*7)+(1*7)=147
147 % 10 = 7
So 54647-77-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO4.C12H23N/c1-9(2)11(12(15)16)14-13(17)18-8-10-6-4-3-5-7-10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h3-7,9,11H,8H2,1-2H3,(H,14,17)(H,15,16);11-13H,1-10H2
54647-77-7Relevant articles and documents
KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS
Hoogwater, D. A.,Peereboom, M.
, p. 5325 - 5332 (2007/10/02)
The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.