54769-26-5

Basic information

• Product Name: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, ethyl ester
• Synonyms: (S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyric acid ethyl ester;Benzyloxycarbonyl-L-valyl-L-valin-ethylester;N-(N-benzyloxycarbonyl-L-valyl)-L-valine ethyl ester
• CAS NO: 54769-26-5
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.46300
• Mol File: 54769-26-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, ethyl ester(54769-26-5)
• EPA Substance Registry System: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, ethyl ester(54769-26-5)

Safety Data

• Hazardous Substances Data: 54769-26-5(Hazardous Substances Data)

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 17609-47-1 L-Valine ethyl ester hydrochloride 
• 54769-22-1 1-methanesulfonyloxy-1,2,3-benzotriazole 
• 501-53-1 benzyl chloroformate 
• 17431-03-7 L-valine ethyl ester 
• 538-75-0 dicyclohexyl-carbodiimide 
• 54647-77-7 N-[(benzyloxy)carbonyl]-L-valine, compound with dicyclohexylamine (1:1) 

Downstream Products

• 19542-54-2 N-benzyloxycarbonyl-L-valyl-L-valine 

Relevant articles and documents

KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS

The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.

3,3'-(Phenylphosphinylidene)bis and 3,3'-(Phenylphosphinylidene)bis. New Activating Agents

New activating agents, 3,3'-(phenylphophinylidene)bis (4) and 3,3'-(phenylphosphinylidene)bis (5), were readily prepared by the reaction of phenylphosphonic dichloride (3) with 2(3H)-benzoxazolone (1) and 2(3H)-benzothiazolone (2) respectively in the presence of triethylamine at room temperature.The new activating agents 4 and 5 were found to be useful for the preparation of amides, esters, and dipeptides under mild conditions.Furthemore, the direct polycondensation of isophthalic acid with aromatic diamines using the activating agent 4 in the presence of pyridine proceeded fast at room temperature to produce polyamides with inherent viscosities up to 0.80 dL/g.

Synthesis of all the stereoisomers of statine (4-amino-3-hydroxy-6-methylheptanoic acid). Inhibition of pepsin activity by N-carbobenzoxy-L-valyl-L-valyl-statine derived from the four stereoisomers.

Synthesis of all four stereoisomers of the novel amino acid statine, 4-amino-3-hydroxy-6-methylheptanoic acid, found in pepstatin, a potent acid protease inhibitor, has been accomplished. Carbobenzoxy-L-valyl-L-valyl-statine tripeptides derived from all f