51989-25-4 Usage
General Description
8-Deazafolic acid, also known as 7,8-Dihydro-8-oxo-2'-deoxyguanosine, is a synthetic compound derived from folic acid. It is a potent competitive inhibitor of thymidylate synthase and has been studied for its potential antitumor and antiviral activities. 8-Deazafolic acid has shown promise in cancer treatment by disrupting DNA synthesis and inhibiting the growth of cancer cells. Additionally, it has been investigated for its potential in treating viral infections, particularly HIV, by inhibiting the replication of the virus. Overall, 8-deazafolic acid has demonstrated potential therapeutic applications in both cancer and viral diseases, making it an important compound for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 51989-25-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,9,8 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 51989-25:
(7*5)+(6*1)+(5*9)+(4*8)+(3*9)+(2*2)+(1*5)=154
154 % 10 = 4
So 51989-25-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H20N6O6/c21-20-25-13-6-5-12(23-16(13)18(30)26-20)9-22-11-3-1-10(2-4-11)17(29)24-14(19(31)32)7-8-15(27)28/h1-6,14,22H,7-9H2,(H,24,29)(H,27,28)(H,31,32)(H3,21,25,26,30)/t14-/m0/s1
51989-25-4Relevant articles and documents
Pyridopyrimidines. 12. Synthesis of 8-deaza analogues of aminopterin and folic acid
Srinivasan, Ananthachari,Broom, Arthur D.
, p. 1777 - 1781 (2007/10/02)
A new, general approach to the synthesis of numerous 8-deazafolate and 8-deazaaminopterin analogues is described. The key intermediate, 6-(acetoxymethyl)-2,4-dichloropyrido[3,2-d]pyrimidine, was prepared by chlorination of the 2,4-dioxo derivative which,
