78711-30-5

Basic information

• Product Name: 2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one
• CAS NO: 78711-30-5
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.1753
• Mol File: 78711-30-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.6°C at 760 mmHg
• Flash Point: 201.5°C
• Density: 1.57g/cm³
• Vapor Pressure: 6.43E-07mmHg at 25°C
• Refractive Index: 1.762
• CAS DataBase Reference: 2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one(78711-30-5)
• EPA Substance Registry System: 2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one(78711-30-5)

Safety Data

• Hazardous Substances Data: 78711-30-5(Hazardous Substances Data)

Usage

Chemical compound

2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one

Family

Pyrido[3,2-d]pyrimidin-4(1H)-one

Role

Important component of nucleic acids like DNA and RNA

Classification

Purine base

Function

Critical role in the structure and function of genetic material

Involvement

Formation of adenosine triphosphate (ATP)

Precursor for

Adenosine and adenosine monophosphate (AMP)

Significance

Widely studied in biochemistry, pharmacology, and molecular biology

Upstream product

• 82933-87-7 2,4-diamino-6-methyl-pyrido<3,2-d>pyrimidine 
• 78711-28-1 2-chloro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one 
• 30212-52-3 2,4-dichloropyrido<3,2-d>pyrimidine 

Downstream Products

• 78711-31-6 2-amino-4(3H)-oxopyrido<3,2-d>pyrimidine-6-carboxylic acid 
• 78711-34-9 2-amino-5,6,7,8-tetrahydro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one trifluoroacetate 
• 246160-30-5 2-(4-{[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 246160-31-6 2-(4-{acryloyl-[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 246160-32-7 C₄₆H₅₅N₉O₁₄ 
• 246160-33-8 C₅₈H₆₆N₉O₁₆P 
• 51989-25-4 8-Deazafolic Acid 
• 78711-35-0 N-<4-<<(2-amino-4(3H)-oxopyrido<3,2-d>pyrimidin-6-yl)carbonyl>amino>benzoyl>-L-glutamic acid 
• 78711-39-4 (S)-2-{4-[(2-Acetylamino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 76807-52-8 2-amino-6-hydroxymethyl-4-(3H)-pyrido<3,2-d>pyrimidinone 

Relevant articles and documents

Pyridopyrimidines. 14. Conformational Studies of 5,6,7,8-Tetrahydropyridopyrimidines. Potential Multisubstrate Analogue Inhibitors of Thymidylate Synthetase

The synthesis of 5-pyrimidin-5-yl)methyl>-2'deoxyuridine and a number of related compounds as models of potent inhibitors of thymidylate synthetase has been accomplished.The 1H and 13C NMR spectra of certain of these molecules show unusual and remarkably stable conformational effects.A partial conformational analysis was undertaken in order to determine the origins of these effects.These studies revealed that the presence of a diastereomeric center at C-6 is responsible for the observed phenomena.

New synthesis of N-[4-[(2-amin-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives

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