52074-58-5

Basic information

• Product Name: 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, ethyl ester
• CAS NO: 52074-58-5
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.343
• Mol File: 52074-58-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, ethyl ester(52074-58-5)
• EPA Substance Registry System: 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, ethyl ester(52074-58-5)

Safety Data

• Hazardous Substances Data: 52074-58-5(Hazardous Substances Data)

Upstream product

• 52074-60-9 (5-chlorocarbonyl-1-methyl-pyrrol-2-yl)-acetic acid ethyl ester 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 83863-74-5 2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid 
• 94133-60-5 C₁₀H₁₃NO₄ 
• 49669-45-6 ethyl (1-methyl-1H-pyrrol-2-yl)acetate 
• 874-60-2 4-methyl-benzoyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 6279-86-3 methanetricarboxylic acid triethyl ester 
• 62128-31-8 (1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone 
• 55895-62-0 2-(4-methylbenzoyl)pyrrole 
• 3278-34-0 ethyl 2-(ethoxythiocarbonylthio)acetate 
• 17310-31-5 di-p-tolyl-cadmium 
• 10108-64-2 cadmium(II) chloride 
• 63833-44-3 morpholino(p-tolyl)methanone 

Downstream Products

• 26171-23-3 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid 

Relevant articles and documents

Synthetic method of non-steroidal antiinflammatory drug pain killing

The invention discloses a synthesis method of non-steroidal anti-inflammatory drug tolmetin. The methodcomprises the following steps: sequentially preparing a sulfuric acid-containing acetonedicarboxylic acid crude product, 2-(2-acetoxy)-1-methyl-1H-pyrrole-3-formic acid and 2-(2-alkyl acetate)-1-methyl-1H-pyrrole-3-formic acid by taking citric acid or citric acid monohydrate as a raw material; and carrying out decarboxylation, acylation, hydrolysis and acidification to obtain tolmetin. The synthetic method provided by the invention overcomes the defect that the existing tolmetin preparation process depends on N-methylpyrrole, and is a low-cost, low-pollution and high-yield synthetic method of non-steroidal anti-inflammatory drug tolmetin.

Solvent free oxidative radical substitution process. Synthesis of pyrrole fused systems

A xanthate-based, solvent free, homolytic substitution on selected substituted pyrrole systems is described. Additionally, a practical entry for the rapid construction of pyrrole fused systems using this solventless radical addition followed by a double nucleophilic alkylation sequence, is also reported.

Homolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane

An efficient homolytic aromatic substitution of pyrroles, furan and thiophene by ·CH2CO2Et and ·CH(CH3)CO2Et has been carried out the radicals being generated by autoxidation of BEt3 in the presence of XCH2CO2Et and XCH(CH3)CO2Et(X=Br, I).