5216-35-3

Basic information

• Product Name: 1,2-Bis(4-chlorophenyl)ethane
• Synonyms: 1,2-Bis(4-chlorophenyl)ethane
• CAS NO: 5216-35-3
• Molecular Formula: C₁₄H₁₂Cl₂
• Molecular Weight: 251.1511
• Mol File: 5216-35-3.mol
• Article Data: 71

Chemical Properties

• Boiling Point: 319.2°Cat760mmHg
• Flash Point: 133°C
• Appearance: /
• Density: 1.214g/cm³
• CAS DataBase Reference: 1,2-Bis(4-chlorophenyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(4-chlorophenyl)ethane(5216-35-3)
• EPA Substance Registry System: 1,2-Bis(4-chlorophenyl)ethane(5216-35-3)

Safety Data

• Hazardous Substances Data: 5216-35-3(Hazardous Substances Data)

Usage

Description

1,2-Bis(4-chlorophenyl)ethane, also known as Clobutinol Hydrochloride (C583600(M)), is a chemical compound with the molecular formula C16H13Cl2. It is a derivative of 1,2-diphenylethane, where two hydrogen atoms on the ethane chain are replaced by two 4-chlorophenyl groups. 1,2-Bis(4-chlorophenyl)ethane has been found to have various applications in different industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
1,2-Bis(4-chlorophenyl)ethane is used as an active pharmaceutical ingredient for the treatment of acute respiratory diseases. It is known as Clobutinol Hydrochloride, a non-narcotic antitussive drug that helps in suppressing cough reflexes and providing relief from coughing.
Used in Chemical Research:
1,2-Bis(4-chlorophenyl)ethane is used as a research compound for studying the effect of solvent on photolysis of 3-chloroand 4-chloro substituted benzyl chlorides. This application is crucial in understanding the behavior of similar compounds under various conditions and can contribute to the development of new chemical processes and products.

Upstream product

• 106-43-4 para-chlorotoluene 
• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 107-06-2 1,2-dichloro-ethane 
• 108-90-7 chlorobenzene 
• 622-95-7 4-chlorobenzyl bromide 
• 1571-08-0 methyl 4-formylbenzoate 
• 1820-42-4 bis(4-chlorophenyl)acetylene 
• 15107-35-4 Triphenyl-<1,2-bis-(4-chlorphenyl)-aethyl>-phosphoniumchlorid 
• 874-72-6 4-chlorobenzylmagnesium chloride 
• 75-91-2 tert.-butylhydroperoxide 
• 15945-07-0 2,4,5-trichlorobenzensulfonyl chloride 
• 1118-71-4 2,2,6,6-tetramethylheptane-3,5-dione 
• 71017-85-1 1-(4-chlorobenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate 

Downstream Products

• 74-11-3 para-chlorobenzoic acid 
• 24012-41-7 5-Phenyl-2,3,4-tris-(p-chlor-phenyl)-(αββ')-cyclopentadien-(2,4)-on-(1) 
• 81540-32-1 4,5-di-(4-chlorophenyl)-2-(4-(4,5-di(4-chlorophenyl)-1H-imidazol-2-yl)phenyl)-1H-imidazole 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 939983-56-9 3,4-bis(4-chlorophenyl)-1,2,5-thiadiazole 1,1-dioxide 

Relevant articles and documents

Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.

The synergy between the CsPbBr3nanoparticle surface and the organic ligand becomes manifest in a demanding carbon-carbon coupling reaction

We demonstrate here the suitability of CsPbBr3nanoparticles as photosensitizers for a demanding photoredox catalytic homo- and cross-coupling of alkyl bromides at room temperature by merely using visible light and an electron donor, thanks to the cooperative action between the nanoparticle surface and organic capping.

Method for preparation of bibenzyl compounds by photocatalytic one-step process

The invention relates to a brand new low-cost method for synthesis of bibenzyl compounds. The method adopts green and clean light energy as the reaction energy, and takes toluene or a toluene derivative as the raw material to prepare bibenzyl compounds under the catalysis of a solid photocatalyst. The method is carried out at room temperature, and can prepare bibenzyl compounds directly by illumination. The reaction process includes: mixing a toluene derivative, a catalyst and a solvent, then putting the mixture into a pressure-resistant quartz container (larger than 1MPa), and performing replacement with inert gas, conducting illumination stirring at room temperature, and carrying out reaction for 1 or more hour. At the end of the reaction, the catalyst can be easily separated from the reaction system and can be recycled repeatedly, the reaction product can be separated by crystallization, and the yield of bibenzyl compounds can reach 3.21g (g catalyst)h. The method can be used for direct preparation of 1, 2-diphenylethane and natural bibenzyl drugs.