939983-56-9

Basic information

• Product Name: 1,2,5-Thiadiazole, 3,4-bis(4-chlorophenyl)-, 1,1-dioxide
• Synonyms: 1,2,5-Thiadiazole, 3,4-bis(4-chlorophenyl)-, 1,1-dioxide;3,4-bis(4-chlorophenyl)-1,2,5-thiadiazole 1,1-dioxide
• CAS NO: 939983-56-9
• Molecular Formula: C₁₄H₈Cl₂N₂O₂S
• Molecular Weight: 339.19652
• Mol File: 939983-56-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,5-Thiadiazole, 3,4-bis(4-chlorophenyl)-, 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Thiadiazole, 3,4-bis(4-chlorophenyl)-, 1,1-dioxide(939983-56-9)
• EPA Substance Registry System: 1,2,5-Thiadiazole, 3,4-bis(4-chlorophenyl)-, 1,1-dioxide(939983-56-9)

Safety Data

• Hazardous Substances Data: 939983-56-9(Hazardous Substances Data)

Usage

Chemical class

Heterocyclic organic compound

Common use

Building block for the synthesis of biologically active molecules and drugs

Pharmaceutical applications

Development of new drugs for cancer, inflammation, and microbial infections

Biological activities

Diverse, with potential for various therapeutic applications

Agricultural potential

Being explored as a pesticide

Versatility

Promising applications in both pharmaceutical and agricultural industries

Chemical structure

1,2,5-Thiadiazole core with 3,4-bis(4-chlorophenyl) substitution and 1,1-dioxide functional group

Upstream product

• 5216-35-3 1,2-bis(4-chlorophenyl)ethane 
• 3457-46-3 4,4'-dichlorobenzil 
• 7803-58-9 SULFAMIDE 
• 4254-20-0 4,4'-dichlorobenzoin 

Downstream Products

• 939983-58-1 3,4-bis-(4-chloro-phenyl)-3-methyl-2,3-dihydro-[1,2,5]thiadiazole 1,1-dioxide 

Relevant articles and documents

Solvent-Free Condensation Reactions to Synthesize Five-Membered Heterocycles Containing the Sulfamide Fragment

We report a study of the solvent-free condensation reaction of 1,2-dicarbonyl compounds with sulfamide catalyzed by a Keggin-type acid (H3PMo12O40·nH2O, MPA) to obtain 3,4-disubstituted 1,2,5-thiadiazole 1,1-dioxide derivatives. Some reactions were also performed in solution or using nano-sized silica-supported MPA catalyst in order to compare the results under different experimental conditions. Effects of the temperature used for the thermal pretreatment of the catalyst, the reaction temperature, the molar ratios sulfamide/1,2-dicarbonyl compound and MPA/1,2-dicarbonyl compound, and alternative experimental procedures on the yield of the reaction product were investigated. Under suitable experimental conditions eight compounds were obtained in good yields. The catalyst was recycled and reused, but with some loss of its catalytic activity. The presented synthetic method is a simple, clean, and environmentally friendly alternative for synthesizing different 1,2,5-thiadiazole 1,1-dioxide derivatives.

IMIDAZOTHIAZOLE DERIVATIVES

There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula