522592-59-2Relevant articles and documents
Synthesis of Benzofuranones via Palladium-Catalyzed Intramolecular Alkoxycarbonylation of Alkenylphenols
Hirschbeck, Vera,Fleischer, Ivana
supporting information, p. 2854 - 2857 (2018/02/06)
Herein, a new catalytic system to synthesize benzofuranones is reported. A palladium-catalyzed intramolecular alkoxycarbonylation is employed to generate 3-substituted-benzofuran-2(3H)-ones from alkenylphenols under mild reaction conditions, linked to an ex situ formation of CO from N-formylsaccharin. The carefully chosen catalytic system enables an efficient reaction with a novel functional group tolerance, despite the high polymerization tendency of the starting material.
Substrate-directed hydroacylation: Rhodium-catalyzed coupling of vinylphenols and nonchelating aldehydes
Murphy, Stephen K.,Bruch, Achim,Dong, Vy M.
supporting information, p. 2455 - 2459 (2014/03/21)
We report a protocol for the hydroacylation of vinylphenols with aryl, alkenyl, and alkyl aldehydes to form branched products with high selectivity. This cross-coupling yields α-aryl ketones that can be cyclized to benzofurans, and it enables access to eu
Palladium-catalyzed asymmetric intermolecular cyclization
Hu, Jian,Hirao, Hajime,Li, Yongxin,Zhou, Jianrong
supporting information, p. 8676 - 8680 (2013/09/12)
Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric syn
