52260-00-1

Basic information

• Product Name: 2-Thiophenesulfonic acid, hydrazide
• Synonyms: 2-thiophenesulfonohydrazide;2-Thiophenesulfonic acid,hydrazide;hydrazino-2-thienylsulfone
• CAS NO: 52260-00-1
• Molecular Formula: C4H6N2O2S2
• Molecular Weight: 178.236
• Mol File: 52260-00-1.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 2-Thiophenesulfonic acid, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenesulfonic acid, hydrazide(52260-00-1)
• EPA Substance Registry System: 2-Thiophenesulfonic acid, hydrazide(52260-00-1)

Safety Data

• Hazardous Substances Data: 52260-00-1(Hazardous Substances Data)

Upstream product

• 16629-19-9 thiophene-2-sulfonyl chloride 
• 52665-48-2 furan-2-sulfonyl chloride 

Downstream Products

• 79280-02-7 thiophene-2-sulfonic acid benzylidenehydrazide 
• 79280-04-9 4-Hydroxy-1-(thiophen-2-sulfonylhydrazonomethyl)-benzol 
• 79280-08-3 4-Methoxy-1-(thiophen-2-sulfonylhydrazonomethyl)-benzol 
• 80467-18-1 N-benzoyl-N'-thiophene-2-sulfonohydrazide 
• 80467-19-2 N,N'-dibenzoyl-N'thiophene-2-sulfonohydrazide 
• 79280-07-2 4-Dimethylamino-1-(thiophen-2-sulfonylhydrazonomethyl)-benzol 
• 75968-28-4 glyoxylic acid 2-thienylsulfonylhydrazone 
• 34566-08-0 (E)-2-(styrylsulfonyl)naphthalene 
• 135-00-2 2-Benzoylthiophene 
• 34243-33-9 2-thiophen-2-yl-quinoline 
• 1492039-29-8 1-phenyl-2-((thiophen-2-yl)sulfonyl)ethan-1-one 
• 16629-19-9 thiophene-2-sulfonyl chloride 

Relevant articles and documents

Electrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives

Herein, we report a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources (RSO2NHNH2) and Et3N·3HF as cost-effective fluorination reagents under mild conditions. Remarkably, this

Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols

An unprecedented electrochemical heterodifunctionalization of α-CF3alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.