79280-04-9Relevant articles and documents
THE REACTIONS OF SOME THIOPHENE SULFONYL DERIVATVES
Cremlyn, Richard J.,Goulding, Kenneth H.,Swinbourne, Frederick J.,Yung, Kin-Man
, p. 111 - 120 (2007/10/02)
Thiophene-2-sulfonyl chloride has been allowed to react with 7 amines, hydrazine and sodium azide.The hydrazide was converted into 21 hydrazones.The azide reacts with cyclohexene, norbornene and triphenylphosphine.The sulfonyl chloride with chlorosulfonic acid gave a mixture of the 2,4- and 2,5-bis-sulfonyl chlorides (2:1).These were not separated by conversion to amides, azides, hydrazides, or hydrazones. 2-Carboxythiophene with chlorosulfonic acid gave a mixture of the 4- and 5-sulfonyl chlorides (9:1), conversion to amides and recrystallization gave the 4-sulfonamides.Chlorosulfonation of 2-carboxamido- and 2-N,N-dimethylcarboxamidothiophene gave the 4-sulfonyl chlorides, characterized as amides, hydrazides and 18 hydrazones.Some N-arylthiophenesulfonamides were condensed with trichloromethylsulfonyl chloride.The i.r., n.m.r. and mass spectra of the various thiophenesulphonyl derivatives are discussed.