52267-51-3

Basic information

• Product Name: Acetic acid, diazo-, phenylmethyl ester
• Synonyms: benzyl diazoacetate
• CAS NO: 52267-51-3
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol File: 52267-51-3.mol
• Article Data: 37

Chemical Properties

• Flash Point: 7℃
• Density: 0.894 g/mL at 25 °C
• Refractive Index: n20/D1.504
• CAS DataBase Reference: Acetic acid, diazo-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, diazo-, phenylmethyl ester(52267-51-3)
• EPA Substance Registry System: Acetic acid, diazo-, phenylmethyl ester(52267-51-3)

Safety Data

• Hazardous Substances Data: 52267-51-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1738-68-7 Gly-OBz 
• 941-55-9 4-toluenesulfonyl azide 
• 5396-89-4 benzyl acetoacetate 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 
• 100-51-6 benzyl alcohol 
• 52267-50-2 benzyl-α-diazo-acetoacetate 
• 5437-45-6 Benzyl bromoacetate 
• 14661-69-9 p-toluenesulfonylhydrazone glyoxylic acid chloride 
• 79844-27-2 Malonic acid benzyl ester 4-oxo-azetidin-2-yl ester 
• 186581-53-3 diazomethane 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 108985-35-9 Boc-Gly-Glc-OBn 
• 30450-80-7 N-Benzyloxycarbonyl-glycyl-glykolsaeure-benzylester 
• 443988-46-3 benzyl 2-trimethylsilyl-2-diazoacetate 
• 443988-47-4 benzyl 2-triethylsilyl-2-diazoacetate 
• 443988-50-9 benzyl 2-dimethyl(phenyl)silyl-2-diazoacetate 
• 294846-96-1 benzyl 2-[tert-butyl(dimethyl)silyl]-2-diazoacetate 
• 622-06-0 dibenzyl maleate 
• 538-64-7 dibenzyl fumarate 
• 621-13-6 dicyclohexyl cis-butenedioate 
• 141-05-9 Diethyl maleate 

Relevant articles and documents

Comparative study on post-polymerization modification of C1 poly(benzyl 2-ylidene-acetate) and its C2 analog poly(benzyl acrylate)

The present study investigates the challenging approach of post-polymerization modification on polymers with a sterically demanding reaction center. Therefore, the general possibility to functionalize polymethylene moieties was investigated. Poly(benzyl 2-ylidene-acetate) was synthesized by polymerization of benzyl 2-diazoacetate utilizing [(L-prolinate)RhI(1,5-dimethyl-1,5-cyclooctadiene)] as a catalyst. Subsequently, the modification of C1 polymerized poly(benzyl 2-ylidene-acetate) with amines was analyzed and the obtained data set was compared with experimental data derived for the C2 analog poly(benzyl acrylate). This is the first study on post-polymerization modification utilizing densely functionalized polymethylenes as starting materials.

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).