5234-26-4

Basic information

• Product Name: N-(2-ACETYL-PHENYL)-ACETAMIDE
• Synonyms: N-(2-ACETYL-PHENYL)-ACETAMIDE;2'-(Acetylamino)acetophenone;o-Acetylaminoacetophenone;2'-Acetamidoacetophenone;N-(2-ethanoylphenyl)ethanamide
• CAS NO: 5234-26-4
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 5234-26-4.mol
• Article Data: 59

Chemical Properties

• Melting Point: 77 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 367.4 °C at 760 mmHg
• Flash Point: 165.1 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.57
• PKA: 14.56±0.70(Predicted)
• CAS DataBase Reference: N-(2-ACETYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-ACETYL-PHENYL)-ACETAMIDE(5234-26-4)
• EPA Substance Registry System: N-(2-ACETYL-PHENYL)-ACETAMIDE(5234-26-4)

Safety Data

• Hazardous Substances Data: 5234-26-4(Hazardous Substances Data)

Usage

General Description

N-(2-Acetyl-phenyl)-acetamide, also known as N-acetylphenyl acetamide, is a chemical compound with the molecular formula C10H11NO2. It is a derivative of acetaminophen and is commonly used as an analgesic and antipyretic agent. N-(2-Acetyl-phenyl)-acetamide is often used in over-the-counter pain relief medications and is known for its mild to moderate pain-relieving effects. It works by inhibiting the production of prostaglandins, which are responsible for causing pain and fever. N-(2-ACETYL-PHENYL)-ACETAMIDE is considered safe when used in appropriate doses and is widely used as an active ingredient in various pharmaceutical products.

InChI:InChI=1/C10H11NO2/c1-7(12)9-5-3-4-6-10(9)11-8(2)13/h3-6H,1-2H3,(H,11,13)

Upstream product

• 91-55-4 2,3-dimethylindole 
• 13177-23-6 2,3-dimethyl-3-(hydroperoxy)indolenine 
• 108-24-7 acetic anhydride 
• 551-93-9 2-aminoacetophenone 
• 59587-26-7 4a-hydroperoxy-N⁵-ethyl-N³-methyllumiflavin 
• 150370-71-1 N-acetyl-N-(2-acetylphenyl)acetamide 
• 75-36-5 acetyl chloride 
• 67152-54-9 2,3-dimethyl-3-(methylperoxy)indolenine 
• 7732-18-5 water 
• 61403-29-0 N-(2-ethynylphenyl)acetamide 
• 16714-26-4 1-(2-azido-phenyl)-ethanone 
• 64-19-7 acetic acid 
• 108-22-5 Isopropenyl acetate 
• 150370-66-4 3-Acetyl-2a,7b-dihydro-2a,7b-dimethyl-1,2-dioxetoindole 

Downstream Products

• 551-93-9 2-aminoacetophenone 
• 607-67-0 4-hydroxy-2-methylquinoline 
• 607-66-9 4-methyl-1,2-dihydroquinolin-2-one 
• 607-66-9 4-methylquinolin-2-ol 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 32375-61-4 2-(2-acetamidophenyl)-2-oxoacetic acid 
• 41019-20-9 N-(2-acetyl-4-nitro-phenyl)-acetamide 
• 194784-10-6 acetic acid-(2-acetyl-6-nitro-anilide) 
• 85976-21-2 N-(4-bromo-2-(2,2-dibromoacetyl)phenyl)acetamide 
• 101585-79-9 1-(2-acetylamino-phenyl)-ethanone-(methyl-phenyl-hydrazone) 
• 131423-38-6 [E]-3-phenyl-1-(2-acetamidophenyl)prop-2-en-1-one 
• 136490-89-6 (E)-N-[2-[3-(4-methoxyphenyl)-1-oxo-2-propenyl]phenyl]acetamide 
• 41797-86-8 2-(2-acetylamino-phenyl)-propan-2-ol 
• 89937-04-2 N-[2-(1-Hydroxy-1-phenyl-ethyl)-phenyl]-acetamide 

Relevant articles and documents

An Iron(III) Superoxide Corrole from Iron(II) and Dioxygen

A new structurally characterized ferrous corrole [FeII(ttppc)]? (1) binds one equivalent of dioxygen to form [FeIII(O2?.)(ttppc)]? (2). This complex exhibits a 16/18O2-isotope sensitive ν(O-O) stretch at 1128 cm?1 concomitantly with a single ν(Fe-O2) at 555 cm?1, indicating it is an η1-superoxo (“end-on”) iron(III) complex. Complex 2 is the first well characterized Fe-O2 corrole, and mediates the following biologically relevant oxidation reactions: dioxygenation of an indole derivative, and H-atom abstraction from an activated O?H bond.

Oxidative Cleavage of Indoles Mediated by Urea Hydrogen Peroxide or H2O2 in Polar Solvents

The oxidative cleavage of indoles (Witkop oxidation) involving the use of H2O2 or urea hydrogen peroxide in combination with a polar solvent has been described. Among these solvents, 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) stands out as the one affording the corresponding 2-ketoacetanilides generally in higher yields The protocol described has also enabled the oxidation of different pyrroles and furans derivatives. Furthermore, the procedure was implemented in a larger-scale and HFIP was distilled from the reaction mixture and reused (up to 4 cycles) without a significant detriment in the reaction outcome, which remarks its sustainability and applicability. (Figure presented.).

Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.