52661-56-0

Basic information

• Product Name: (E)-3-(5-nitro-2-furyl)acrylaldehyde
• Synonyms: (E)-3-(5-nitro-2-furyl)acrylaldehyde;(E)-3-(5-Nitro-2-furanyl)propenal;Einecs 258-078-9;(E)-3-(5-Nitrofuran-2-yl)acrylaldehyde
• CAS NO: 52661-56-0
• Molecular Formula: C₇H₅NO₄
• Molecular Weight: 167.1189
• EINECS: 258-078-9
• Mol File: 52661-56-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 310.7°Cat760mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.365g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• CAS DataBase Reference: (E)-3-(5-nitro-2-furyl)acrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(5-nitro-2-furyl)acrylaldehyde(52661-56-0)
• EPA Substance Registry System: (E)-3-(5-nitro-2-furyl)acrylaldehyde(52661-56-0)

Safety Data

• Hazardous Substances Data: 52661-56-0(Hazardous Substances Data)

Usage

Description

(E)-3-(5-nitro-2-furyl)acrylaldehyde is an organic compound characterized by its molecular structure that features a nitro group, a furyl group, and an acrylaldehyde group. It is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
(E)-3-(5-nitro-2-furyl)acrylaldehyde is used as a reactant/reagent for the synthesis of hydrazone and diacylhydrazine derivatives. These derivatives serve as ERAD (Endoplasmic Reticulum-Associated Degradation) inhibitors, which are useful in the treatment of various diseases. (E)-3-(5-nitro-2-furyl)acrylaldehyde's ability to form these derivatives makes it a valuable starting material in the development of new therapeutic agents.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 3642, 1958 DOI: 10.1021/ja01547a043

InChI:InChI=1/C7H5NO4/c9-5-1-2-6-3-4-7(12-6)8(10)11/h1-5H/b2-1+

Downstream Products

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• 1338244-74-8 5-(p-bromophenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-76-0 5-(p-chlorophenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-70-4 5-(p-methylphenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-73-7 5-(p-nitrophenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-72-6 5-(p-hydroxyphenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-71-5 5-(p-methoxyphenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-69-1 5-phenyl-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1338244-75-9 5-(p-iodophenyl)-N-(3-(5-nitrofur-2-yl)allylidene)-1,3,4-thiadiazol-2-amine 
• 1359738-69-4 (S)-6-methyl-3-(5-nitrofuran-2-yl)-2-(p-tolylsulfonyl)-2,3-dihydropyridazine-4-carbaldehyde 
• 95356-86-8 6-[(E)-3-(5-Nitro-furan-2-yl)-prop-2-en-(Z)-ylidene]-3-phenyl-thiazolo[2,3-c][1,2,4]triazol-5-one 
• 78960-64-2 7-(2-Hydroxy-3-phenoxy-propyl)-1,3-dimethyl-8-{N'-[(Z)-3-(5-nitro-furan-2-yl)-prop-2-en-(Z)-ylidene]-hydrazino}-3,7-dihydro-purine-2,6-dione