52753-91-0Relevant articles and documents
A solvent- And catalyst-free tandem reaction: Synthesis, and photophysical and biological applications of isoindoloquinazolinones
Ali, Sk Asraf,Bera, Anirban,Ikbal, Mohammed,Manna, Susanta Kumar,Misra, Sandip,Saha, Amit,Samanta, Shubhankar
supporting information, p. 4324 - 4331 (2020/03/26)
An easy green synthetic approach for fused isoindoloquinazolinones has been developed under neat reaction (yields up to 91%) conditions. This new one-pot tandem methodology involves condensation of readily available anthranilamide with 3-(2-formylcycloalk
Rhodium-catalyzed ortho-C-H olefination of aromatic aldehydes employing transient directing strategy
Liu, Xi,Wang, Zhonghao,Chen, Qun,He, Ming-Yang,Wang, Liang
, (2018/02/07)
A Rhodium(III)-catalyzed ortho-C-H olefination of aromatic aldehydes in the presence of catalytic amount of TsNH2 has been developed. The in situ generated imine intermediate from aldehyde and TsNH2 worked as a transient directing gr
CoIII-Carbene Radical Approach to Substituted 1H-Indenes
Das, Braja Gopal,Chirila, Andrei,Tromp, Moniek,Reek, Joost N. H.,De Bruin, Bas
supporting information, p. 8968 - 8975 (2016/07/30)
A new strategy for the catalytic synthesis of substituted 1H-indenes via metalloradical activation of o-cinnamyl N-tosyl hydrazones is presented, taking advantage of the intrinsic reactivity of a CoIII carbene radical intermediate. The reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of functionalized 1H-indene derivatives. The cheap and easy to prepare low spin cobalt(II) complex [CoII(MeTAA)] (MeTAA = tetramethyltetraaza[14]annulene) proved to be the most active catalyst among those investigated, which demonstrates catalytic carbene radical reactivity for a nonporphyrin cobalt(II) complex, and for the first time catalytic activity of [CoII(MeTAA)] in general. The methodology has been successfully applied to a broad range of substrates, producing 1H-indenes in good to excellent yields. The metallo-radical catalyzed indene synthesis in this paper represents a unique example of a net (formal) intramolecular carbene insertion reaction into a vinylic C(sp2)-H bond, made possible by a controlled radical ring-closure process of the carbene radical intermediate involved. The mechanism was investigated computationally, and the results were confirmed by a series of supporting experimental reactions. Density functional theory calculations reveal a stepwise process involving activation of the diazo compound leading to formation of a CoIII-carbene radical, followed by radical ring-closure to produce an indanyl/benzyl radical intermediate. Subsequent indene product elimination involving a 1,2-hydrogen transfer step regenerates the catalyst. Trapping experiments using 2,2,6,6-tetra-methylpiperidine-1-oxyl (TEMPO) radical or dibenzoylperoxide (DBPO) confirm the involvement of cobalt(III) carbene radical intermediates. Electron paramagnetic resonance spectroscopic spin-trapping experiments using phenyl N-tert-butylnitrone (PBN) reveal the radical nature of the reaction.
